Now, researchers at Johns Hopkins Medicine report that
a novel laboratory tool that lets them find virus mutations faster and more efficiently than ever before has identified a biological mechanism that appears to play a big role in helping HCV evade both the natural immune system and vaccines.
Not exact matches
The international team's design and testing of this
novel advanced material from scratch required multidisciplinary expertise and sophisticated
tools from such places as Argonne National
Laboratory and ORNL, including Argonne's Advanced Photon Source and ORNL's Center for Nanophase Materials Science, says Lee.
The Bergthaler
laboratory pursues an integrative approach comprising infection models and
tools of immunology, pathology and systems biology in order to dissect
novel disease - relevant interactions between pathogens and the host.
Because of the ease with which the CRISPR / Cas9 system can be applied, it has quickly become a robust
tool for generating accurate genetic disease models in the
laboratory and for identifying
novel therapeutic targets in the clinic.
Her
laboratory focuses on (1) the use of next generation sequencing to define the microbiome and host immunologic features in patients with human diseases and (2) developing custom computational
tools for the identification of
novel human commensals and pathogens in these inpatient populations, and (3) using statistical and functional biological methods to understand the complex interplay between the human microbiome and host biology.