Sentences with phrase «novel lead compounds»
Not exact matches
«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.
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Novel natural compounds may lead to safe and inexpensive repellents that undercut skeeters» ability to sense their human prey
«These findings should lead to the rational design of R - ATAs based on this structural information to develop novel biocatalysts useful for the production of a diverse range of chiral amine compounds.
PsychoGenics has pioneered the translation of rodent behavioral responses into robust, high throughput, high content phenotyping and its drug discovery platforms, SmartCube ®, NeuroCube ®, and PhenoCube ® have led to shared risk partnerships with major pharma companies such as Sunovion and Roche and resulted in the discovery of several novel compounds now in clinical trials or advanced preclinical development.
In order to explore new pharmacophore moieties, FC131 was used as a lead compound for the development of novel CXCR4 antagonists.
The company is based around novel compounds, including NAV - 847, discovered and developed by the cross-functional drug discovery team within IACS led by Philip Jones, Ph.D., executive director and head of drug discovery at IACS.
SciLifeLab and the EU Lead Factory, a collaborative public - private partnership aiming to deliver innovative drug discovery starting points by e.g. giving free access to up to 500,000 novel compounds, declare to exploit the complementarity and synergistic -LSB-...]
In a discovery screen profiling 102 cell lines against 8,400 compounds, PRISM led the researchers to a specific novel compound, BRD - 7880; the specific action against cell lines in the panel rapidly led them to discover that this compound worked by inhibiting aurora kinase B, an enzyme involved in cell division that is abnormally regulated in several cancers.
Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.