Sentences with phrase «novel mechanism of»

A high - fat meal induces low - grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Stuart L. Schreiber, PhD Director, Center for the Science of Therapeutics, Broad Institute Morris Loeb Professor of Chemistry and Chemical Biology, Harvard University Talk title: Novel mechanism of action (nMoA) compounds in therapeutics discovery

In this breed, the researchers found a novel mechanism of regulating blood sugar levels via an interaction of genes located on two different chromosomes.

Pandey SC, Ugale R, Zhang H, Tang L, Prakash A. Brain chromatin remodeling: a novel mechanism of alcoholism.

Kulkarni A, Al - Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez - Rodriguez L, Mehnert JM, and Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma.

Because of its novel mechanism of action, AST - OPC1 could also potentially benefit patients with other neurological disorders associated with de-myelination, such as multiple sclerosis and white matter stroke.

Bouvardin is a Radiation Modulator with a Novel Mechanism of Action.

Ullu was recognized for her lab's work with the protozoan parasite Trypanosoma brucei, which causes African sleeping sickness, to uncover a novel mechanism of gene silencing known as RNA interference.

α3β1 integrin regulates MMP - 9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin - mediated MMP gene expression.

Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.

CRI Investigator Gabriel Rabinovich and his team identify a novel mechanism of T cell homeostasis based on differential glycosylation of T helper cell subsets.

A team led by Dr. Thorsten Eierhoff and Junior Professor Dr. Winfried Römer from the Institute of Biology II, members of the Cluster of Excellence BIOSS Centre for Biological Signalling Studies of the University of Freiburg, has identified a novel mechanism of bacterial invasion: Pseudomonas aeruginosa uses lipids in the cell membrane to make its way into host cells.

The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.

The Surrey team hopes that the novel mechanism of spring - loaded steel booms that is to deploy its sail will work as well in space as it has on Earth.

«Identifying a novel mechanism of action is a prerequisite to understanding a disorder, and to development of therapeutic interventions,» Mei said.

In doing so, a novel mechanism of regulation was identified, and a protein known as SPV - 1 shown to maintain regular cycles of actomyosin contractility.

Whoops, I stepped in it: A novel mechanism of honey bee (Apis mellifera) pollination of blueberries.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

It demonstrates a completely novel mechanism of predisposition to diabetes that could lead to novel therapies,» says Adrian Vella, M.D., Mayo Clinic endocrinologist and senior author of the study.

Scientists have elucidated a novel mechanism of electron emission from matter caused by x-rays.

Commenting on the study for ESMO, Dr Olivier Michielin, head of Personalised Analytical Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, said: «Omaveloxolone's novel mechanism of action is to block MDSCs, cells known to suppress the immune response.

The company believes the drug is the first anti-depression drug with a novel mechanism of action in 30 years, and preparations for launch are underway now.

Meanwhile, Van den Eynde and his team are already hard at work looking for the other novel mechanisms of immune suppression in their model.

«There is an urgent clinical need for new treatments for depression with novel mechanisms of action.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

Researchers from the Department of Biomedicine at the University of Basel discovered novel mechanisms of cell migration by observing cells moving on lines of connective tissue.

The major players in the arthritis drug market include Remicade ® (infliximab), Humira ® (adalimumab), Enbrel ® (etanercept), Cimzia ® (certolizumab pegol) and Simponi ® (golimumab), while biosimilars of the above as well as new drugs with novel mechanisms of action are under development.

Thus, we seek to identify novel mechanisms of cardiac and renal injury in order to aid and improve diagnostic, therapeutic, and preventive strategies in this high - risk population of patients.

Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms.

An internationally renowned expert in the field of gender - based biology, he has identified a large number of mutations in sex - determining genes, developed animal models with atypical sexual development, and identified novel mechanisms of sex differences in the brain.

February 28 — Matthew Lerner, «Catch Me If You Can: Novel Mechanisms of Social Functioning and Intervention in Youth with Autism Spectrum Disorders»

Not exact matches

And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.

Innovations in distribution mechanisms (facebook, iphone / ipad, other «social») make it possible for startups to appear compelling without having to actually solve the distribution problem in a novel way, just assume garnering success on one of these platforms.

Through its novel insulin sensitizing mechanism of action, MSDC - 0602K has potential to resolve the underlying pathophysiology of NASH.

High profits may be justified if novel products offer significant benefits to patients (thus producing indirect economic value through the patients» restored health) or if they represent significant pharmacologic advances over their predecessors — offering new mechanisms of actions and emblematic of high - risk research.

Ripatrazone devotes considerable attention to Ron Hansen's 1991 novel Mariette in Ecstasy, which he sees as «a postconciliar method to regain lay participation in the mechanisms of the Church.»

The change in allele frequency may arise by any number of mechanisms including the addition of a novel allele via mutation.

The molecular mechanisms providing «novel information» are well understood and these mechanisms have been directly tracked within real - time observations of speciation events.

The priorities now lie not with technological development but with social invention — the creation of new mechanisms of problem solving, novel forms of social organization, innovative life - styles, and so on.

«This novel technique,» they said, «should help distinguish and monitor cancer stages and progression, aid in elucidation of basic mechanisms underlying tumorigenesis, and facilitate analyses of processes related to early detection of cancer, screening and / or cancer risk assessment.»

Building on the work of several other research groups, my collaborator Giuseppe Lodato and I published a set of papers in 2006 and 2007 in which we proposed a novel mechanism that could have produced more massive black hole seeds from the get - go.

The researchers have found indications from 3D structure modelling that this new version of the toxin may possess a novel targeting mechanism, which could enable it to treat a wider range of conditions.

A Ludwig Cancer Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunotherapy.

In the new study, Bhullar and his colleagues detail a novel approach to finding the molecular mechanism involved in creating the skeleton of the beak.

The next step would be to explore the mechanisms through which bone marrow lesions might influence the progression of osteoarthritis and whether this could lead to a novel treatment.»

This work confirmed these suspicions and discovered novel molecular genetic mechanisms driving the evolution of HPV - inactive cancers.

«This discovery demonstrates the effect the gut microbiome has on the immune system and unearths a novel mechanism via which changes in the gut microbiome can increase the risk of autoimmune disorders.

Researchers from Instituto de Medicina Molecular (iMM) João Lobo Antunes have found a mechanism through which certain types of leukemia resist chemotherapy, thus revealing novel molecular targets that may be used to improve the efficiency of this type of treatment.

«This finding opens up a huge avenue of research in parrots, in trying to understand how parrots are processing the information necessary to copy novel sounds and what are the mechanisms that underlie imitation of human speech sounds,» said Mukta Chakraborty, a post-doctoral researcher in the lab of Erich Jarvis, an associate professor of neurobiology at Duke and a Howard Hughes Medical Institute Investigator.

«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.