Sentences with phrase «novel mechanism of resistance»
The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.
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His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.
A novel mechanism — similar to how normal tissue stem cells respond to wounding — might explain why bladder cancer stem cells actively contribute to chemo - resistance after multiple cycles of chemotherapy drug treatment.
«Using a novel model we developed to facilitate discoveries about the growth and spread of lymph node metastases, we show that angiogenesis does not occur in lymph node metastases, providing a mechanism for resistance to angiogenic therapy in these situations.»
Dr Daniel Martin, Senior Lecturer and Honorary Consultant, UCL Division of Surgery and Interventional Science and Director of UCL CASE Medicine, adds: «These exciting results give us a unique insight into the possible mechanism of insulin resistance in diabetes and provide some clues as to where we should be thinking about focusing further research on novel treatments for this disease.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Masters Student, Rotation, Dept. of Plant Pathology December 2005 — April 2006 Cornell University, Geneva, NY Principal Investigator: Dr. Chris Smart The lab focuses on the identification of novel plant defense mechanisms under field conditions and is looking at the relationship between pathogen and insect resistance.
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.
Correlative nanomechanical profiling with super-resolution F - actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells Sharma S, Santiskulvong C, Bentolila, L A, Rao J, Dorigo O and Gimzewski J K 2012 Nanomedicine: Nanotechnology, Biology, and Medicine 8 757 - 766
This target identification platform is used to identify novel targets and rational combinations and mechanisms of resistance to our current programs.
Kulkarni A, Al - Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez - Rodriguez L, Mehnert JM, and Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma.
My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.