Sentences with phrase «novel mouse model»

the generation of novel mouse models of Cystic Fibrosis by exploring genetically - diverse murine populations that will provide unique tools for disease modeling and pre-clinical studies.

We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo.

Currently, the Hu lab continues to analyze the functions of ER proteins in malignant progression of leukemia using novel mouse models, in which we selectively deleted genes that encode critical ER - resident proteins that support the growth and survival of leukemia.

However, Walker Jackson, a former postdoctoral researcher in Lindquist's lab is changing that, creating novel mouse models of human fatal familial insomnia (FFI) and CJD.

The researchers are planning to use the novel mouse model to study how ErbB4 may coordinate brain activities, in an effort to learn more about mechanisms behind attention deficit disorders.

The study used a novel mouse model to study brain functions.

To overcome this challenge, Lowe and his team used a genetic technique to precisely and reversibly disrupt Apc activity in a novel mouse model of colorectal cancer.

To corroborate the findings, the researchers also developed a novel mouse model that was deficient for autophagy specifically in beta cells with expression of the human form of islet amyloid polypeptide.

A cancer drug that has shown promise against Alzheimer's disease (AD) in mice and has begun early clinical trials has yielded perplexing results in a novel mouse model of AD that mimics the genetics and pathology of the human disease more closely than any other animal model.

The authors unveil a novel mouse model of chromosome Xq22.1 deletion syndrome, a human disease characterized by developmental delay, intellectual disability, epilepsy, dysmorphic features, and an X-linked pattern of inheritance.

December 14, 2015 Brain cell death is a possible trigger of multiple sclerosis Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medicine.

It will also study a novel mouse model that lacks the Unkempt gene in developing nerve cells in the brain.

At Sanofi I worked in a preclinical group, working with a team to develop a novel mouse model.

At the Buck, Demaria began working with a novel mouse model of senescence and completed his PhD.