Results: Subchronic PCP treatment induced deficits in episodic memory, cognitive flexibility and social functioning, assessed via
the novel object recognition, cued reversal learning and social interaction tests.
Treated AD mice also displayed improved performance on three memory tasks: the Y - maze,
the novel object recognition test, and the active place avoidance task.
Administration of clozapine attenuated PCP - induced deficits in
novel object recognition and social interaction tests but clozapine alone induced deficits in the 5 - CSRTT and DMTP tasks.
Deficits in
Novel Object Recognition and Location task.
Professor Bischofberger and co-investigators Stefanie Heigele, PhD, and Leoni Bolz tested two groups of mice, which were housed either without (sedentary) or with running wheels (voluntarily running) using
a novel object recognition (NOR) task to assess learning and long - term memory.
In a study testing
novel object recognition and location, piglets interacted with these objects.
Not exact matches
Novel location
recognition, or piglets» ability to remember where a familiar
object is located, is likely controlled by the hippocampus.
In two separate
novel -
object recognition tests, the CA2 - deficient mice showed a normal preference for an
object they had not previously encountered, showing that the mice did not have a global lack of interest in novelty.
Increased time spent exploring the
novel object was interpreted as successful
recognition memory for the familiar
objects versus the
novel one.
(A) Exploration times of the
objects in the
novel and familiar location, respectively, during the test of the
object place
recognition task.
We will highlight the
novel insights created this way for a diverse set of visual capacities such as
object recognition, action
recognition, decision making and plasticity.