Sentences with phrase «novel research discoveries»

His clinical interests include arthroscopy, total joint arthroplasty, biological approach to joint surgery, minimally invasive fracture treatment, and application of novel research discoveries (such as stem cell and regenerative medicine technologies) to clinical patients.

She is interested in translating novel research discoveries, including regenerative medicine and lubricin therapy, to equine clinical patients with musculoskeletal disease.

Not exact matches

In January 2017, SiteOne announced the closing of a research and development agreement with Amgen, a collaboration focused on combining SiteOne's experienced drug discovery team and portfolio of novel Naᵥ1.7 inhibitors with Amgen's neuroscience capabilities.

In 1996, Alexandria founded Alexandria Venture Investments to actively invest at the cutting edge of novel, breakthrough discoveries in biopharmaceuticals, diagnostics, research tools, medical devices, digital health, and technology.

Lakatos defines a research programme as «progressive» if in the long run it leads to the discovery of novel phenomena and previously unexpected facts as well as accounting for facts already known.

You need to bring your energy, passion, vision, and enthusiasm for the complex and challenging tasks we encounter in scientific research, especially the groundbreaking, novel approaches encountered in accelerating the translation from discovery to improved clinical practice.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

Research teams focused on both cutaneous and uveal melanoma are fast - tracking discoveries into the clinical setting, and bringing novel therapeutic options to patients in the Philadelphia region,» said Karen Knudsen, Director of the Sidney Kimmel Cancer Center.

After a successful postdoc at the Ontario Cancer Institute, where he developed a proprietary platform for the discovery of novel cancer therapeutic agents, Bray was asked to join the former Amgen Research Institute in Toronto (now called the Advanced Medical Discovery Institute and no longer part of the parent company) as the head of their quantitative biology group and act as liaison to Amgen Inc. in California.

During the webinar, our expert panel of researchers will discuss: • Strategies and technologies for successful cancer biomarker discovery through robust detection and analysis of miRNAs in biofluids • Research into analytic and biological variables that impact miRNA measurements in serum and plasma from the clinical pathologist's point of view • The novel application of miRNAs in serum as biomarkers of aging and chronic disease • The answers to questions submitted by the live, online viewers.

The current research findings build upon recent discoveries including novel identification of key genetic changes in cells of the immune system.

Not only does this discovery suggest that statins could help prevent or reduce the severity of asthma symptoms resulting from colds, but may also open the doors to further research into novel ways of controlling asthma attacks.

HHS Secretary Kathleen Sebelius explains that NCATs will «offer innovative approaches to the development pipeline, provide novel approaches to diagnostics and therapeutics development, stimulate new avenues for basic scientific discovery, and complement existing NIH and private sector research.»

Led by Assistant Professor Darren Chian Siau Chen from the Department of Civil and Environmental Engineering, the NUS research team made this novel discovery after conducting tests where projectiles of various shapes and masses were fired against a silica sand block.

«This study provides us exciting new information about how this virus is released from infected cells and opens the door for novel antiviral drug discovery research.

This new discovery, funded by multiple groups, opens up novel possibilities for future research aimed at developing vaccines against these viruses to prevent type 1 diabetes.

«Some novel research on nanomaterials used to capture carbon dioxide from burning fossil fuels actually led us to this discovery,» said McGrail.

The designation recognizes the Center's collaborative environment and expertise in harnessing translational research to bridge scientific discovery to clinical delivery, with the ultimate goal of successfully introducing novel diagnostic, therapeutic and preventive approaches to cancer.

Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.

Non-exclusive licenses are available for research and sale of products and services across multiple fields including: research tools, kits, reagents; discovery of novel targets for therapeutic intervention; cell lines for discovery and screening of novel drug candidates; GMP production of healthcare products; production of industrial materials such as enzymes, biofuels and chemicals; and synthetic biology.

Nanotheraputics for Antibiotic Resistent Emerging Bacterial pathogens (NAREB) European Research Infrastructures for Poverty Related Diseases (EURIPED) Biomarkers for enhanced vaccines immunosafety (BioVacSafe) European network of vaccine research and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBResearch Infrastructures for Poverty Related Diseases (EURIPED) Biomarkers for enhanced vaccines immunosafety (BioVacSafe) European network of vaccine research and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBresearch and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

While translational research has traditionally moved basic immunology knowledge forward into clinical application, varying clinical presentations of human immune - related disease processes, as well as variability in therapeutic outcomes, have provided opportunities for discovery of novel mechanistic hypotheses directly from patients.

His other major discovery in antiviral research is the development of a novel microorganism based assay for antiviral drugs called «MOBA.»

The publication of the discovery of leptin by (3) Zhang and Friedman et al (1994) created worldwide interest in this novel peptide as a tool for research and therapeutic discovery for obesity and its related disorders.

He also held several positions of increasing leadership at Praecis Pharmaceuticals, including Director of Cell Biology, where he initiated or contributed to the establishment of numerous research projects focusing on the discovery of novel therapeutics for the treatment of cancer, inflammation, infectious disease, and neurological disorders.

Along with other research in this area, Schreiber's HDAC discovery and his novel «signaling network model» of chromatin revealed the genetic complex to be not just a simple structural element, but one with a key regulatory function that is central to epigenetics.

Our current research focuses on the discovery and functional characterization of novel proteins, the rational engineering of proteins with improved functional properties, and de novo design of molecular scaffolds for a variety of biotechnological and biomedical applications.

The course will introduce students to planning and executing novel research studies as well as the analyses associated with documenting scientific discoveries and deriving supported conclusions based upon these data.

Cenix BioScience is a contract research organization focused on the discovery and pre-clinical development of novel therapeutics, specializing in advanced applications of RNA interference (RNAi) gene silencing combined with high content phenotyping in cultured cells in vitro and in animals in vivo.

Building on existing clinical research at MD Anderson Cancer Center through collaborations and membership to the RNA Center to create a ncRNA - centric effort to drive discovery of molecular markers of cancer by evaluating, co-developing, facilitating and disseminating novel ncRNA technologies.

The initiative aims to strengthen collaborations between SBP scientists, expand the range of scientific expertise and research capabilities and foster research alliances with industry partners working in neuroscience and drug discovery research with the ultimate goal of translating novel ideas and discoveries into therapies that improve the life of patients suffering from brain diseases.

Consistent with a pioneering legacy of leadership in not - for - profit biomedical research and a track record of life - saving contributions in immunology and cell biology, The Wistar Institute aims to pursue novel and courageous research paths to life science discovery, and to accelerate / potentiate the impact of those discoveries by shortening the path from bench to bedside.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

There her research focused on inventing molecular, bead and array - based approaches to enable novel vaccine discovery against infectious and chronic diseases At the University of Texas Southwestern Medical she pursued technologies that became the basis of a Texas biotechnology company that was ultimately acquired by MacroGenics, Inc..

Funding provided by the Cancer Center Support Grant (CCSG) supports several types of pilot projects (1) highly innovative pilot projects focusing on proof - of - concept or translational research; (2) preliminary collaborative investigations that lead to multi-investigator grant awards or clinical trial; (3) projects that closely align with the Cancer Center's strategic plan and enhance key initiatives; and (4) pilot funding for junior investigators to jump - start independent projects or for more senior investigators looking to study a novel idea derived from discovery.

Continuing its rich history of discoveries and biomedical breakthroughs, Wistar today is an international leader in basic biomedical research in cancer and infectious diseases, with a focus on discoveries leading to the development of novel therapies and vaccines.

Mike Friedlander, the executive director of the Virginia Tech Carilion Research Institute (VTCRI) and associate provost for health sciences, and David Kingston, a University Distinguished Professor and director of the new Virginia Tech Center for Drug Discovery (VTCDD), presented an overview to the Board of Visitors about Virginia Tech advances in human health, novel research programs, technology licensing, start - up companies, and drug discovery and deveResearch Institute (VTCRI) and associate provost for health sciences, and David Kingston, a University Distinguished Professor and director of the new Virginia Tech Center for Drug Discovery (VTCDD), presented an overview to the Board of Visitors about Virginia Tech advances in human health, novel research programs, technology licensing, start - up companies, and drug discovery and deveresearch programs, technology licensing, start - up companies, and drug discovery and development.

This research has enabled novel gene discovery and uncovered the different genetic mechanisms underlying both isolated congenital heart disease and that which occurs in association with other medical problems.

Dr. Jason Yustein's research interests include furthering the biological, molecular and genetic understanding of pediatric sarcomas, including osteosarcoma and Ewing's sarcoma, through the formation of novel model systems that will lead to the discovery of new therapeutic targets and subsequent development of new treatment interventions.

Despite ongoing efforts toward finding novel entities for the treatment of the most challenging cancers, translation into patient benefit has been slow due to the fact that translational cancer research from early drug discovery to late stage drug development and assessment in clinical trials is a long process.

Prior research had developed a number of new compounds making use of a novel drug discovery paradigm which begins with natural products extracted from plants; it then entails selecting synthetic derivatives which demonstrate efficacy in multiple assays testing protection against different factors of the nerve cell damage and death which take place in brain injuries and in age - associated neurodegenerative conditions.

In the present, Aaron Eckhart plays Roland Michell, an American research assistant (British in the novel) who makes the startling discovery that presumed - faithful married poet Randolph Henry Ash (Jeremy Northam) may have romanced presumed - lesbian poet Christabel LaMotte (Jennifer Ehle).

-- Wall Street Journal «A harrowing, clever, incomparable riff on life in Kim Jong Il's North Korea» — San Francisco Chronicle «Magnificently accomplished... Part thriller, part coming - of - age novel, part romance, The Orphan Master's Son is made sturdy by research... but what makes it so absorbing isn't its documentary realism but the dark flight of the author's imagination... rich with a sense of discovery... The year is young, but The Orphan Master's Son has an early lead on novel of 2012» — The Daily Beast «Providing a rare glimpse into one of the world's least known countries, Adam Johnson weaves a tale of hardship, romance, and redemption in North Korea in The Orphan Master's Son.»

«This is a significant accomplishment that reflects Avigen's strategic efforts to identify novel mechanisms to treat neurologic disorders and to protect the know - how and intellectual property of our scientific discoveries,» stated Kirk Johnson, Ph.D., Vice President of Research and Development at Avigen.

Internal funding for research will not only provide desperately needed resources in a time when funding is difficult to obtain from federal sources and foundations, but will also allow students and mentors to think Outside The Box, test novel ideas and undertake unique research leading to breakthrough discoveries in animal health and welfare.

A collaborative research effort by a team of investigators at the University of Pennsylvania, veterinary ophthalmologist Dr. Chris Dixon and the OptiGen Research Program, has led to the discovery of a novel mutation in the CNGA3 gene that causes Day Blindness in the Labrador Retrieresearch effort by a team of investigators at the University of Pennsylvania, veterinary ophthalmologist Dr. Chris Dixon and the OptiGen Research Program, has led to the discovery of a novel mutation in the CNGA3 gene that causes Day Blindness in the Labrador RetrieResearch Program, has led to the discovery of a novel mutation in the CNGA3 gene that causes Day Blindness in the Labrador Retriever (1).