Sentences with phrase «novel therapeutic»

Oberman's research interest lies in using electrophysiological techniques (such as EEG and TMS and TCS) to investigate neural circuits whose dysfunction may account for the behavioral pathology seen in autism spectrum disorders with the long term goal of developing novel therapeutic interventions.

The aim of this work is to understand how lubricin and HA synergistically enhance joint lubrication, mitigate inflammation and promote cartilage health, with the ultimate goal of developing novel therapeutic strategies for OA.

Dr. Dickinson's research interests are neurooncology and the development and translation of novel therapeutic strategies for primary brain tumors.

«As our understanding of preventable causes of this major cancer progresses, early detection strategies are being developed and novel therapeutic options become available, we enhance our ability to reduce ovarian cancer mortality,» Dr. Paolo Boffetta, the journal's associate editor, wrote in an accompanying editorial.

Dalby KN, Tekedereli I, Lopez - Berestein G, et al: Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer.

A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis.

This vast body of healing knowledge — sometimes referred to as the «Mother of All Healing» — has recently come to the attention of Western medical researchers seeking novel therapeutic compounds.

The final conclusion is that progesterone may ``... provide novel therapeutic strategies for the treatment of sleep disturbances, in particular in the elderly.»

Besides enabling patient stratification, our study allows the identification of novel therapeutic targets for obesity.

Opiate receptor research has paid off both in fundamental understanding of brain function and in the development of novel therapeutic agents.

Investigational New Drug Application (IND)-- a key step in development of a new drug or medical treatment in which the US Food and Drug Administration (FDA) is notified that a novel therapeutic will be used experimentally

The goal of this work is to develop novel therapeutic targets based on increased understanding of the interaction of tumor cells and immune cells.

A deeper understanding of these axes provides a new framework for developing novel therapeutic targets and optimising personalised interventions.

«Without them, and without our partners on the U-M Neurosurgery team, and donors to the Phase One Foundation that support our work, we wouldn't be able to take this important step in testing this novel therapeutic approach.»

Project Title: A high throughput screen for small molecules enhancing the expression of HTTAS - a novel therapeutic strategy for HD

The extraordinary and welcome growth in interest in novel therapeutic platforms, including in cell based immunotherapies, has the potential to transform patient outcomes in a range of acute and chronic diseases.

Omar Abdel - Wahab, MD Memorial Sloan - Kettering Cancer Center New York, NY Identifying Novel Therapeutic Vulnerabilities in Spliceosomal Mutant Leukemias

Novel therapeutic approaches to combat changes in vascular fate and function associated with arteriosclerosis, atherosclerosis and diabetes

Ideally, identification of mediators of the inflammatory response in AMD will yield novel therapeutic approaches to this common and often severe form of blindness, in the form of either blocking or inducing TLR2 signaling events.

72/3: 45 Systems genetics approach unravels the molecular mechanisms underlying lung function variation and uncovers novel therapeutic targets for COPD.

To translate advances in our understanding of molecular mechanisms of oncogenesis and tumor progression into novel therapeutic strategies.With primary focus on lung cancer, melanoma, and lymphoma / leukemia, we will use the strength of in - depth molecular and phenotypic characterization of tumor heterogeneity to identify new targets and translate those into new therapeutic opportunities.

Carcinomas arise from epithelial cells, and tumor progression involves a loss of polarity, so an understanding of cell polarity is important in the identification of novel therapeutic approaches to cancer.

Dr Peter Barlow: «Dr Peter Barlow is funded by a grant from the Chief Scientist Office (Scotland) on a project investigating novel therapeutic approaches for respiratory viral infections.»

«Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005 - 2012,» by Nicholas S. Downing et al., JAMA, January 2014.

The main focus of my research program is on design and preclinical evaluation of novel therapeutic strategies for treatment of metastatic cancers, including breast cancer and melanoma.

Helmsley expanded support with an additional $ 15 million grant in 2010 to create a collaborative stem cell project involving Salk and Columbia University to fast - track the use of induced pluripotent stem cells to gain new insight into disease mechanisms and screen for novel therapeutic drugs.

In September 2016, we announced the first clinical application of our GLAAS discovery platform in Sanofi's Phase 1 clinical trial evaluating a novel therapeutic candidate for the treatment of peanut allergy.

The difficulty in isolating and propagating functional primary cholangiocytes is a major limitation in the study of biliary disorders and the testing of novel therapeutic agents.

Carmot's vision is to become a leader in drug discovery by unlocking novel therapeutic target space not currently accessible to conventional small molecule technologies.

Facilitate cross-disciplinary research programs focused on understanding the biological mechanisms of lymphoid cancers for the development of novel therapeutic treatments for these cancers.

Emerging studies suggest that miRs are novel therapeutic targets for complex diseases.

Therefore, novel therapeutic approaches might be in order.

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches

The goal is to define selective vulnerabilities that can guide novel therapeutic approaches and biomarker development.

These isogenic cell lines can be used not only to understand the cellular consequences of disease mutations, but also to perform high throughput genetic and pharmacological screens to both understand the underlying pathological mechanisms and to develop novel therapeutic agents to prevent or treat such diseases.

Novel therapeutic strategies include inhibitors that target HIF - 1α directly (10) or downstream targets such as VEGF.

Furthermore, the role the host microenvironment plays in tumor biology provides an exceptional opportunity for novel therapeutic strategies.

Our goal is to identify novel therapeutic targets and participate in both preclinical and clinical studies of new drugs and other interventions.

These new understandings may lead to a novel therapeutic approach that improves muscle function in older individuals and in those with chronic diseases.

Here, we investigate the hypothesis that miR - 181a regulates the molecular pathways that control mDA axonal growth, and provide evidence that miR - 181a inhibition may be a novel therapeutic approach for axonal regeneration in PD.

«We believe the use of this index in future studies may help identify novel therapeutic targets against cancer,» Dr. Noushmehr said.

These tumor suppressor genes are two of the most frequently altered genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.

Several novel therapeutic targets have already been identified, and drug discovery efforts continue.

The ability to transform adipocytes into unique fat - burning cells may suggest novel therapeutic strategies for obesity.

These proteins, if their roles in neuroprotection in the retina are fully established in the future by more comprehensive studies, may present novel therapeutic targets in treating retinal disorders including glaucomatous conditions.»

His laboratory is focused on unraveling the molecular mechanisms that underlie several important surgical diseases, including necrotizing enterocolitis and inflammatory bowel disease, and seeks to develop novel therapeutic strategies to prevent or reverse these disease processes.

This study will greatly expand our knowledge of the biological processes within plaques that lead to disease and provide novel therapeutic approaches that aim to achieve long - term oral health by specifically removing cariogenic species and leaving beneficial or harmless populations intact.

The study, led by the SciLifeLab member Marene Landström, might open new possibilities for early detection of aggressive prostate tumors and novel therapeutic strategies.

We report that targeting miR - 181a regulates axonal growth, and that miR - 181a inhibition may be a novel therapeutic approach for axonal regeneration of neurons affected by PD.

These findings offer a novel therapeutic direction in AD and related neurodegenerative diseases.