Sentences with phrase «novel therapeutic agent»
They used publicly available FDA documents to identify 188 novel therapeutic agents for seven years.
https://www.sciencedaily.com/
His staff is highly motivated to disseminate their work via publications and to participate in the discovery and development of novel therapeutic agents.
«Collaborating with the outstanding scientists at Lundbeck, offers great hope for discovering what triggers these diseases and developing novel therapeutic agents.»
In an industry R&D environment, we have extensively applied these methods to the drug discovery process for psychiatric and neurological indications, providing a powerful translational tool to accelerate progression of novel therapeutic agents towards the clinic.
These isogenic cell lines can be used not only to understand the cellular consequences of disease mutations, but also to perform high throughput genetic and pharmacological screens to both understand the underlying pathological mechanisms and to develop novel therapeutic agents to prevent or treat such diseases.
The difficulty in isolating and propagating functional primary cholangiocytes is a major limitation in the study of biliary disorders and the testing of novel therapeutic agents.
«Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005 - 2012,» by Nicholas S. Downing et al., JAMA, January 2014.
Opiate receptor research has paid off both in fundamental understanding of brain function and in the development of novel therapeutic agents.
Not exact matches
After a successful postdoc at the Ontario Cancer Institute, where he developed a proprietary platform for the discovery of novel cancer therapeutic agents, Bray was asked to join the former Amgen Research Institute in Toronto (now called the Advanced Medical Discovery Institute and no longer part of the parent company) as the head of their quantitative biology group and act as liaison to Amgen Inc. in California.
Inducing therapeutic ketosis solely with the ketogenic diet can be difficult, however, so the USF researchers created novel metabolic agents that induce ketosis without dietary restriction.
A team led by Fengzhi Li, PhD, and Xinjiang Wang, PhD, of Roswell Park Cancer Institute (RPCI) has reported new findings regarding therapeutic targets of the novel anticancer agent FL118.
In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape - derived compounds, dihydrocaffeic acid (DHCA) and malvidin - 3» - O - glucoside (Mal - gluc), which might be developed as therapeutic agents for the treatment of depression.
As part of his research, Dr. Chang has defined several novel mechanisms and mediators of action of probiotic organisms that are currently being developed as therapeutic agents.
The journal aims to promote novel concepts, programs, technologies, protocols, therapeutic agents, and alternative approaches for the early detection, intervention and treatment of human malignancies and closely associated diseases.
Langmuir 29 (35), 10973 - 10979 (2013) «Reduced limbic metabolism and fronto - cortical volume in rats vulnerable to alcohol addiction» A. Gozzi, F. Agosta, M. Massi, R. Ciccocioppo, and A. Bifone NeuroImage 69, 112 - 119 (2013) «Polymeric nanocarriers for controlled and enhanced delivery of therapeutic agents to the CNS» M. Gagliardi, G. Bardi and A. Bifone Theraputic Delivery, 3 (7), 875 — 887 (2012), doi: 10.4155 / TDE.12.55 «Neuromapping techniques in drug discovery: pharmacological MRI for the assessment of novel antipsychotics» A. Bifone and A. Gozzi Expert Opinions in Drug Discovery, 7 (11): 1071 - 82 (2012) «Neuroimaging evidence of altered fronto - cortical and striatal function after prolonged self - administration in the rat»
Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma
This novel approach is an alternative to ultrasound, another promising method researchers are studying to get therapeutic agents into the brain.