Sentences with phrase «novel therapeutic approaches in»

«The mechanisms by which circadian rhythms are maintained and the cross talk with metabolic signaling are just beginning to be elucidated,» she says, but they should lead to novel therapeutic approaches in the years ahead.

Therefore, a novel therapeutic approach in inflammatory breast cancer could involve a combination of conventional chemotherapy with small - molecule inhibitors of the Cdk2 cell cycle kinase.

Not exact matches

«At the same time, as the human ZNF217 is associated with poor survival in a variety of cancers, understanding how this protein operates in physiological conditions may help to predict cancer risk, achieve earlier diagnosis and provide novel therapeutic approaches.»

«Our worldwide effort to evaluate this novel therapeutic approach has shown positive results and was safe in patients.»

Dr. Paul R. Sanberg, Distinguished University Professor, a co-author of the paper, concluded that «these novel data showing BSCB damage in subacute and chronic ischemic stroke may lead to development of new therapeutic approaches for patients with ischemic cerebral infarction.»

«Targeting such pathways, as for instance the Wnt pathway presented in this study, may result in the creation of novel therapeutic approaches for frontotemporal dementia.»

«Researchers identify protein role in pathway required for Ebola replication: May provide insight into novel therapeutic approaches.»

To achieve gene editing in mice with thalassemia, professor of therapeutic radiology and of genetics Peter M. Glazer, M.D. and his co-authors developed an alternative approach using a novel combination of nanoparticles, synthetic pieces of DNA, and a simple IV injection.

His primary clinical and research focus is dementia, with specific areas of interest including biomarkers to assist in the diagnosis and understanding of disease mechanisms for Alzheimer's and Parkinson's disease, and translational research using novel therapeutic approaches.

«These studies identify telomeres as a new molecular route implicated in the origin of liver diseases such as cirrhosis, hepatitis or liver cancer, as well as novel therapeutic approaches to prevent and combat them,» concluded the researchers.

As this regulation mechanism mediated by the immune system also plays an important role in other diseases such as leukemia, these findings could lead to novel therapeutic approaches.

The designation recognizes the Center's collaborative environment and expertise in harnessing translational research to bridge scientific discovery to clinical delivery, with the ultimate goal of successfully introducing novel diagnostic, therapeutic and preventive approaches to cancer.

We aim to identify molecular, circuit, and network mechanisms of cognitive dysfunction and to develop novel therapeutic approaches to restore brain functions in AD and related disorders.

Selectivity of the therapeutic approach is achieved by producing an enzyme called E. coli purine nucleoside phosphorylase (PNP) directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself.

Biomedcode offers customized services that include the detailed and in - depth scientific consulting at all stages of designing the best approach for the evaluation of a novel therapeutic.

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

Our group is specifically working on improvement of islet isolation and transplantation protocols in clinical practice and the development of novel therapeutic options in the field of beta cell replacement with a clear translational «bench to bedside» approach by linking experimental research with preclinical and clinical work:

Conference mainly focuses on: • Translational medicine approaches in drug discovery & development • Cardio - Vascular Translational Medicine • Translational Haematology • Translational therapeutics / Novel therapeutic technologies • Clinical and Translational Oncology • Translational Neuroscience...

In addition, we employ high throughput screening (HTS), cheminformatics, and medicinal chemistry of novel small molecule reagents that aid in validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous systeIn addition, we employ high throughput screening (HTS), cheminformatics, and medicinal chemistry of novel small molecule reagents that aid in validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous systein validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous systein understanding the biology of signaling in the central nervous systein the central nervous system.

Dr. Mayer is a key component of the Vanderbilt - Ingram Cancer Center (VICC) Breast Cancer Program, where her role is to implement and conduct investigator - initiated, mechanism - based clinical and translational trials in breast cancer, focusing in novel diagnostic and therapeutic approaches.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

The authors concluded that although the studies included in this review provided important information, double - blinded, sham - controlled phase II and phase III clinical trials with larger sample sizes are needed to validate this novel therapeutic approach.

It has invested more than $ 450 million in research to date, almost 90 percent for translational research; funded testing of more than 100 therapeutic targets for Parkinson's disease (PD); and has undertaken novel industry partnerships to support early - stage promising therapeutic approaches.

Together with our collaborators in other UT Health San Antonio departments, we are currently investigating if prohibiting the accumulation of DNA abnormalities can be used as a novel therapeutic approach for treating MDS.

These tumor suppressor genes are two of the most frequently altered genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.

Here, we investigate the hypothesis that miR - 181a regulates the molecular pathways that control mDA axonal growth, and provide evidence that miR - 181a inhibition may be a novel therapeutic approach for axonal regeneration in PD.

These new understandings may lead to a novel therapeutic approach that improves muscle function in older individuals and in those with chronic diseases.

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches

Therefore, novel therapeutic approaches might be in order.

Carcinomas arise from epithelial cells, and tumor progression involves a loss of polarity, so an understanding of cell polarity is important in the identification of novel therapeutic approaches to cancer.

Ideally, identification of mediators of the inflammatory response in AMD will yield novel therapeutic approaches to this common and often severe form of blindness, in the form of either blocking or inducing TLR2 signaling events.

Novel therapeutic approaches to combat changes in vascular fate and function associated with arteriosclerosis, atherosclerosis and diabetes

«Without them, and without our partners on the U-M Neurosurgery team, and donors to the Phase One Foundation that support our work, we wouldn't be able to take this important step in testing this novel therapeutic approach.»

Modeling mRNA expression heterogeneity in tumors through bimodal profiles is a novel powerful approach with the potential to uncover therapeutic targets that benefit subsets of cancer patients.

Clinical and Regenerative medicine refers to development and implementation of advanced therapeutic approaches that may involve the support of expertise in gene / cell therapy, tissue engineering, pharmacology and pharmacogenomics, development of novel molecular target therapy.

An enhanced understanding of the skin microbiome is necessary to gain insight into microbial involvement in human skin disorders and to enable novel promicrobial and antimicrobial therapeutic approaches for their treatment.

Research Interests Critical care of polytrauma patients, troponin as a biomarker in traumatic myocarditis, the application of Continuous Renal Replacement Therapy (dialysis) for companion animals with acute kidney failure, advanced therapeutic approaches to immune mediated hemolytic anemia, and novel laboratory assessment of coagulopathies (including thromboelastography and platelet aggregometry).