Sentences with phrase «novel therapeutic development»

Not exact matches

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.

Dr. Paul R. Sanberg, Distinguished University Professor, a co-author of the paper, concluded that «these novel data showing BSCB damage in subacute and chronic ischemic stroke may lead to development of new therapeutic approaches for patients with ischemic cerebral infarction.»

Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.

This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.

«Identifying a novel mechanism of action is a prerequisite to understanding a disorder, and to development of therapeutic interventions,» Mei said.

The George lab is currently performing preclinical studies for the future development of novel therapeutic approaches including Deep Brain Stimulation, Optogenetics, Chemogenetics and Precision medicine.

The second focus on my research is the development of novel therapeutic vaccine approaches for cancer.

His staff is highly motivated to disseminate their work via publications and to participate in the discovery and development of novel therapeutic agents.

AMP T2D focuses on type 2 diabetes genetics, seeking to use and supplement the substantial amount of human genetic data available from people with type 2 diabetes, or at risk of developing it, to identify and validate novel molecules and pathways as targets for therapeutic development.

Our group is specifically working on improvement of islet isolation and transplantation protocols in clinical practice and the development of novel therapeutic options in the field of beta cell replacement with a clear translational «bench to bedside» approach by linking experimental research with preclinical and clinical work:

The novel licensing agreement is focused on the discovery of pharmacological molecules offering a therapeutic solution and it is designed to streamline access to intellectual property associated with the SMN gene and thus speed the development of assays, models and other tools that are critical to the discovery process.

Conference mainly focuses on: • Translational medicine approaches in drug discovery & development • Cardio - Vascular Translational Medicine • Translational Haematology • Translational therapeutics / Novel therapeutic technologies • Clinical and Translational Oncology • Translational Neuroscience...

Importantly, newly identified proteins will serve as disease biomarkers and will contribute to the development of novel therapeutic strategies.

The lab recently developed novel LumiFluor ® optical reporters and are now implementing these reporters for the non-invasive, high resolution in vivo optical imaging of tumor development, progression, and response to therapeutic intervention in genetically engineered mouse models (GEMM) of cancer.

University of Chicago Development of novel therapeutic and diagnostic strategies for ovarian cancer

One outcome of such studies might be the development of novel biomarkers of disease states, adverse responses, beneficial responses, exposures, or therapeutic responses.

The goal is to define selective vulnerabilities that can guide novel therapeutic approaches and biomarker development.

Facilitate cross-disciplinary research programs focused on understanding the biological mechanisms of lymphoid cancers for the development of novel therapeutic treatments for these cancers.

Our aim is the development of novel, disease - modifying therapeutic approaches for protein misfolding neurodegenerative diseases.

Dr. Jason Yustein's research interests include furthering the biological, molecular and genetic understanding of pediatric sarcomas, including osteosarcoma and Ewing's sarcoma, through the formation of novel model systems that will lead to the discovery of new therapeutic targets and subsequent development of new treatment interventions.

Although both forms are highly active, ADCs with alkylating IGNs demonstrated a better safety profile, and high therapeutic indices in vivo.23, 24 Here we describe the development and preclinical characterization of a novel CD123 - targeting ADC, IMGN632, consisting of a humanized anti-CD123 antibody conjugated to an alkylating IGN payload via a protease cleavable linker.

Clinical and Regenerative medicine refers to development and implementation of advanced therapeutic approaches that may involve the support of expertise in gene / cell therapy, tissue engineering, pharmacology and pharmacogenomics, development of novel molecular target therapy.

Investigational New Drug Application (IND)-- a key step in development of a new drug or medical treatment in which the US Food and Drug Administration (FDA) is notified that a novel therapeutic will be used experimentally

Opiate receptor research has paid off both in fundamental understanding of brain function and in the development of novel therapeutic agents.

Dr. Dickinson's research interests are neurooncology and the development and translation of novel therapeutic strategies for primary brain tumors.

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