Sentences with phrase «novel therapies in»
Overmyer's expertise as a technologist is bolstering research with Peter Muir, the Melita Grunow Family Professor in the School of Veterinary Medicine at UW - Madison, who is using canine models for osteoarthritis, and with Peter G. Shultz at the Scripps Research Institute who is investigating novel therapies in humans.
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Gene and cell therapies have made important medical advances over the past three decade, developing technologies and testing novel therapies in multiple human clinical trials of many diseases.
These mouse models are accelerating the development of novel therapies in HIV infection and oncology.
The authors concluded that manipulation of the gut microbiota through prebiotics may serve as a novel therapy in the prevention of hypertension.
Not exact matches
Attempting to raise funding for their effort to develop a novel therapy for persistent viral infections, the co-founders, who've been best friends since they grew up together in Philadelphia, were on the verge of giving up and heading back to the east coast when Peter Thiel personally persuaded them to stay in town.
And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.
Novels are particularly rich in their explorations of these issues, though such understanding need not be gained only from novels: In The Therapy of Desire (1994) Nussbaum seeks» not always successfully» to discover in certain Hellenistic thinkers a distinctively philosophical account of the value of the emoNovels are particularly rich in their explorations of these issues, though such understanding need not be gained only from novels: In The Therapy of Desire (1994) Nussbaum seeks» not always successfully» to discover in certain Hellenistic thinkers a distinctively philosophical account of the value of the emotionin their explorations of these issues, though such understanding need not be gained only from novels: In The Therapy of Desire (1994) Nussbaum seeks» not always successfully» to discover in certain Hellenistic thinkers a distinctively philosophical account of the value of the emonovels: In The Therapy of Desire (1994) Nussbaum seeks» not always successfully» to discover in certain Hellenistic thinkers a distinctively philosophical account of the value of the emotionIn The Therapy of Desire (1994) Nussbaum seeks» not always successfully» to discover in certain Hellenistic thinkers a distinctively philosophical account of the value of the emotionin certain Hellenistic thinkers a distinctively philosophical account of the value of the emotions.
«Using Streptozotocin - induced type I diabetes and cornea epithelial wounding experimental models, we made novel observations that may soon lead to innovative therapies to treat DPN and ulcerations of the cornea and skin in diabetic patients,» said Yu.
Using a novel form of gene therapy, scientists from Harvard Medical School and the Massachusetts General Hospital have managed to restore partial hearing and balance in mice born with a genetic condition that affects both.
Thus, mitochondrial rescue agents may be a promising novel strategy for disease - modifying therapy in LRRK2 - related Parkinson's.»
Researchers at the Medical College of Wisconsin (MCW) have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.
While she does not believe music would replace current epilepsy therapy, Charyton said this research suggests music might be a novel intervention used in conjunction with traditional treatment to help prevent seizures in people with epilepsy.
«It is anticipated that this novel compound will have significant efficacy in human melanomas and other cancers either as a stand - alone therapy or in combination with other targeted or immune - based therapies,» explained co-corresponding author Rhoda Alani, MD, the Herbert Mescon Chair of Dermatology at Boston University School of Medicine (BUSM).
«Researchers identify novel mechanism in combination drug therapy for acute myeloid leukemia, other cancers.»
She is interested in novel therapies to prevent and manage HSV infection, such as antiviral agents and vaccines.
The 2015 Nobel Prize in Physiology or Medicine goes to William C. Campbell and Satoshi Ōmura for their discoveries of a medication against roundworm parasites and to Youyou Tu for her discoveries concerning a novel therapy against malaria.
«The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy,» said the study's senior author, Valerie Gouon - Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sinai.
«We wanted to develop a novel strategy with PET imaging for non-invasively determining EGFR mutation status in real - time, predict NSCLC patients who may benefit from EGFR - TKI therapy, and monitor EGFR - TKI treatment outcome.»
This is important because it makes it possible to model almost any autoimmune disease, evaluate new drug therapies, and even identify novel targets in the emerging area of cancer immunotherapies.
Physical chemist Bartosz Grzybowski of Northwestern University in Evanston, Illinois, and colleagues hit upon the droplets while trying to devise novel cancer therapies.
While the findings suggest that drugs targeting ASICs may one day lead to novel therapies for anxiety disorders, Braga noted that «more research is needed to understand the roles that ASIC1a channels play in the brain.»
In a letter to the New England Journal of Medicine, a Massachusetts General Hospital (MGH) research team reports a remarkable treatment response in a patient participating in a clinical trial of a novel immune - system - based cancer therapIn a letter to the New England Journal of Medicine, a Massachusetts General Hospital (MGH) research team reports a remarkable treatment response in a patient participating in a clinical trial of a novel immune - system - based cancer therapin a patient participating in a clinical trial of a novel immune - system - based cancer therapin a clinical trial of a novel immune - system - based cancer therapy.
Meanwhile, his research teams are moving several other novel therapies toward clinical trials, each of which has potential for use in the synergistic model of cancer treatment that Black believes will offer the best hope for his patients.
«While expanding beta cell mass may still be desirable for future diabetes therapy, improving the local environment of the otherwise healthy aged beta cell could prevent age - associated deterioration in glucose homeostasis and thereby promote healthy ageing, which is conceptually novel and highly exciting,» says Per - Olof Berggren.
The clinical trial results, published online in the Journal of Allergy and Clinical Immunology: In Practice, suggest that Verapamil represents a promising novel therapy for the treatment of CRS with nasal polypin the Journal of Allergy and Clinical Immunology: In Practice, suggest that Verapamil represents a promising novel therapy for the treatment of CRS with nasal polypIn Practice, suggest that Verapamil represents a promising novel therapy for the treatment of CRS with nasal polyps.
The study, «Non-toxic metabolic management of metastatic cancer in VM mice: novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy,» was published online today in PLOS ONE.
A team of researchers from the Hyperbaric Biomedical Research Laboratory at the University of South Florida (USF) doubled survival time in an aggressive metastatic cancer model using a novel combination of non-toxic dietary and hyperbaric oxygen therapies.
Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.
«Nanoparticles combine photodynamic and molecular therapies against pancreatic cancer: Novel drug - delivery system cuts off common treatment escape pathways in animal models.»
Because the precise activation of Hox genes is essential for a cell's fate, «the research should prove extremely useful in developing novel embryonic stem cell - based therapies, Mazzoni adds.
Still, many in the field are calling the work a major breakthrough, and say the findings could point to new therapies, as well as a novel mechanism for neurodegeneration.
Dr. Levine directs the Clinical Cell and Vaccine Production Facility (CVPF), which develops, manufactures, and tests novel cell and gene therapies in clinical trials at Penn and collaborating institutions.
Schiffman plans to use what he's learned in elephants as a strategy for developing novel cancer - fighting therapies.
«The addition of osteocalcin as a metabolic regulator may one day lead to novel therapies, but we need to understand much better how it works and how it fits into physiology before such therapies can be attempted in humans,» says endocrinologist Mitch Lazar, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania.
The study authors write that using the LSC17 score to single out high - risk patients predicted to have resistant disease «provides clinicians with a rapid and powerful tool to identify AML patients who are less likely to be cured by standard therapy and who could be enrolled in trials evaluating novel upfront or post-remission strategies.»
Then came an invitation to participate in a novel form of gene therapy, one that could mark a first step toward a true cure for AIDS.
A number of immuno - oncology therapies on the horizon tackle this problem in novel ways.
One GSC subtype called the mesenchymal GSC is more malignant and the most therapy - resistant, so Nakano and fellow researchers reasoned that identifying the regulatory molecules active in mesenchymal GSCs might lead to novel and effective therapeutics.
In this project — «PROBE: PROton Beam Extension for Imaging and Therapy» project — a prototype will be built of a novel high - frequency linac that can boost the energy of protons from the 250 Mega-electron volts (MeV) available from conventional medical cyclotrons to 350 MeV, sufficient for imaging all patients.
Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified novel genomic and molecular characteristics of cervical cancer that will aid in the subclassification of the disease and may help target therapies that are most appropriate for each patient.
Four people with paraplegia are able to voluntarily move previously paralyzed muscles as a result of a novel therapy that involves electrical stimulation of the spinal cord, according to a study funded in part by the National Institutes of Health and the Christopher & Dana Reeve Foundation.
Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.
These therapies could enhance the effects of novel cancer immunotherapies when used in combination, resulting in better health outcomes for cancer patients.
«At Exeter we are already developing specific psychological therapies, running clinical trials of novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective therapies and to allow us to use current treatments in a more focussed way.»
«The idea of targeted alpha therapy is not completely novel,» explains Clemens Kratochwil, MD, University Hospital Heidelberg in Germany.
With this novel approach, the researchers found that the therapy reduced the virus in the brain, preventing harm to nerve cells.
«This novel combination therapy simultaneously targets multiple pathways contributing to metastasis» explains Professor Augustin, «On the one hand, we inhibit the growth of new blood vessels in metastases.
In the future, epigenetic editing could also be used to design novel therapies by initiating permanent changes to cell biology.
Findings of a three - year clinical trial led by University of Cincinnati (UC) transplant researchers suggest that a novel pre-operative drug therapy reduces antibodies in kidney patients with greater success than with traditional methods, with the potential to increase the patients» candidacy for kidney transplantation and decrease the likelihood of organ rejection.
«Using a novel model we developed to facilitate discoveries about the growth and spread of lymph node metastases, we show that angiogenesis does not occur in lymph node metastases, providing a mechanism for resistance to angiogenic therapy in these situations.»