Sentences with phrase «novel treatment strategies in»

Our findings indicate that ApoE4 genotype - induced mitochondrial changes and associated structural damage may explain age - dependent pathology seen in AD, indicating potential for novel treatment strategies in the near future.

Our strategy is to use screening techniques to uncover new players followed by validation in gene targeted mice (conventional and conditional transgenesis) in order to test novel treatment strategies in a joint translational research activity.

Not exact matches

«We wanted to develop a novel strategy with PET imaging for non-invasively determining EGFR mutation status in real - time, predict NSCLC patients who may benefit from EGFR - TKI therapy, and monitor EGFR - TKI treatment outcome.»

If we want to change the death rate, we need to increase the investment in understanding the biology of pancreatic cancer and identifying novel treatment strategies,» said co-author and pancreatic cancer surgeon Dr. Michael Choti, Chairman of Surgery, who holds the Hall and Mary Lucile Shannon Distinguished Chair in Surgery.

The study, which is published today in the Journal of Clinical Hypertension and is supported by Barts Charity, devised a novel treatment strategy for 55 patients, involving fractional dosing with tablets (halving or quartering pills), liquid formulations of antihypertensive drugs and patch formulations of antihypertensive drugs — plus use of unlicensed drugs that lower blood pressure.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

«In reviewing this patient's case, I think we might have found a novel strategy of using pre-emptive steroids and sirolimus to mitigate organ rejection in transplant patients receiving cancer treatment involving PD - 1 inhibitors,» said Dr. Jhaveri, associate chief of the Division of Kidney Diseases and Hypertension in Northwell Health's Department of Internal MedicinIn reviewing this patient's case, I think we might have found a novel strategy of using pre-emptive steroids and sirolimus to mitigate organ rejection in transplant patients receiving cancer treatment involving PD - 1 inhibitors,» said Dr. Jhaveri, associate chief of the Division of Kidney Diseases and Hypertension in Northwell Health's Department of Internal Medicinin transplant patients receiving cancer treatment involving PD - 1 inhibitors,» said Dr. Jhaveri, associate chief of the Division of Kidney Diseases and Hypertension in Northwell Health's Department of Internal Medicinin Northwell Health's Department of Internal Medicine.

Fernández warns, «Given the obesity epidemic in the US and worldwide, an increase in those affected by non-alcoholic fatty liver disease is expected in the coming decades and we still do not have a suitable treatment for this condition; A fundamental understanding of this medical problem is therefore essential for development of novel treatment strategies.»

The treatment strategy uses a novel «cancer terminator virus» (CTV), which replicates exclusively in cancer cells delivering the cancer - specific, toxic cytokine gene mda - 7 / IL - 24 directly to the tumor.

In addition to basic research, Jülich's Institute of Complex Systems (ICS - 6) is also developing a novel treatment strategy with its own drug candidate.

They integrated university -, government -, and industry - based researchers from the United States and Canada in a combined effort to define the testable prospects of this novel treatment strategy for HIV - AIDS.

Mohindra, Smita Grade: 7 Home School - Yorktown Heights, NY Project Title: Novel Strategies in the Treatment of Vertebrobasilar Insufficiency Using Sensors

In conclusion, the results of the present study demonstrate the effect of Hyssopus officinalis L. on chronic asthma, and may provide a novel therapeutic strategy for the treatment of chronic asthma.

Along with our nonprofit partners, this program aims to collect, organize, and validate massive amounts of data generated by clinical trials across our global trial network sites in order to generate novel insights into biomarkers for safety and efficacy, novel treatment strategies, and personalization of treatment regimens.

The screening proposed here is expected to lead to novel strategies for the treatment of centronuclear myopathies by reducing muscle weakness caused by central nuclei in diseased muscles.

In addition, understanding the genetic differences between the subpopulations could lead to novel treatment strategies aimed at eliminating tumor cell communities.

This finding reveals unexpected roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease, as well as suggesting novel strategies for its treatment.

Should collaborations like these prove to be important also in human breast cancer, disrupting key interactions may be a novel treatment strategy for the disease.

For patients seeking treatment for a wide range of challenging conditions, Partners HealthCare's wealth of clinical trials offer access to novel therapies or treatment strategies otherwise unavailable in the normal course of care.

The clinical consequences of the molecular results are discussed in Molecular Tumor Boards for novel treatment strategies.

These studies may lead to novel strategies to target DNA damage response and checkpoint proteins as well as chromatin remodeling pathways in cancer treatment

In addition, I work closely with colleagues in Lineberger on innovative clinical trials and translational research projects directed at developing novel strategies for the treatment of advanced diseasIn addition, I work closely with colleagues in Lineberger on innovative clinical trials and translational research projects directed at developing novel strategies for the treatment of advanced diseasin Lineberger on innovative clinical trials and translational research projects directed at developing novel strategies for the treatment of advanced disease.

The concept of tailoring drugs to regulate and treat abnormal brain blood vessels is a novel treatment strategy and offers great potential to complement existing treatments of this debilitating disease,» commented Dr Matthew Campbell, assistant professor in neurovascular genetics at TCD.

My interests lie in leveraging the information hidden in large - scale omics data for better understanding of the mutational processes causing human cancer, for identifying potential cancer prevention strategies, and for developing novel approaches for targeted cancer treatment.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorderin the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorderin various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorderin adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorderin preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorderin animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorderIn genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

The final conclusion is that progesterone may ``... provide novel therapeutic strategies for the treatment of sleep disturbances, in particular in the elderly.»

Researchers will investigate novel methods of measuring chronic pain hypersensitivity in cats with osteoarthritis and other degenerative joint diseases to improve diagnostic and treatment strategies.

Partner with board - certified specialists in Cornell's neurology services when your patients» lives - and the quality of their lives; - depend on access to state - of - the - art technology, novel treatment strategies, and board - certified specialists who are dedicated to diagnosing, treating, and rehabilitating all categories of disease involving the central and peripheral nervous systems.

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