Sentences with phrase «novo protein design»
Not exact matches
Particular emphasis is placed on virtual screening, de novo design, evaluation of drug - likeness, and advanced methods for determining protein - ligand binding.
http://science.sciencemag.org/
Oligonucleotide probes (60 - mers) were designed based on approximately 12,000 genes predicted to encode proteins retrieved from a recent de novo assembly of 454 - sequenced EST libraries of S. pistillata (Karako - Lampert et al., 2014).
De novo rational design of molecular scaffolds mimicking protein interactions for specific interference in cell signaling processes: We apply molecular modelling and computer simulation techniques for designing molecules with pharmacological / biotechnological interest.
Our current research focuses on the discovery and functional characterization of novel proteins, the rational engineering of proteins with improved functional properties, and de novo design of molecular scaffolds for a variety of biotechnological and biomedical applications.
Specifically we seek to de novo design proteins to bind small molecule ligands with high selectivity.