Sentences with phrase «nuclear export»

A Phase 1/2 Open - label Study of the Safety, Tolerability and Efficacy of the Selective Inhibitor of Nuclear Export (SINE) Compound KPT - 8602 in Patients with Relapsed / Refractory Cancer Indications

The combined treatment of ActD with leptomycin B, a small molecule nuclear export inhibitor, has been shown to successfully lead to the accumulation of transcriptionally active p53 in the nuclei of human papillomavirus positive cervical carcinoma cells, resulting in apoptosis of the cells [16].

The HIV genes that do remain are very important for viral production: Gag (structural precursor protein), Pol (polymerase), Tat (viral transactivator for transcriptional activation from the 5» LTR) and Rev (facilitates nuclear export of transcripts).

The protein binds to RNA in the nucleus to form «small nuclear ribonucleoproteins,» which help splice the messenger RNA of many other genes, in preparation for nuclear export and transcription.

Blocking nuclear export seemed to prevent cells from dying and counteracted the defects in neurons with mutant Huntingtin, the researchers say.

The first in her family to earn a doctoral degree, Dr. Higa completed her thesis at the University of Utah in Oncological Sciences where she studied the roles of nuclear pore proteins in nuclear export and nuclear envelope breakdown.

Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1 - dependent nuclear export.

Woodchuck hepatitis virus post-transcriptional regulatory element; sequence that stimulates the expression of transgenes via increased nuclear export.

However, while heme has been reported to induce nuclear export and subsequent cytoplasmic degradation of Bach1, HPP - 4382 does not appear to alter the steady - state levels or nuclear - cytoplasmic distribution of Bach1 (data not shown), suggesting that HPP - 4382 may not fully mimic the action of heme as a ligand of Bach1.

CARM 1 promotes nuclear export of special class of RNAs (3/15/15) Assistant Professor Donghang Cheng, Ph.D. in Dr. Mark Bedford's group was the co-corresponding author on a study demonstrating that in the absence of the arginine methyltransferase CARM1, a certain class of protein encoding RNAs remain in the nucleus.

We develop microscopy to observe and quantify single mRNAs in neuronal processes, and can follow the mRNA from transcription through nuclear export, translation and degradation.

Thomas Lloyd, M.D., Ph.D., of Johns Hopkins University, will test nuclear export inhibitors as a strategy for treatment in ALS due to the C9orf72 mutation.

Environmental Progress is working with our friends and allies in South Korea to save its nuclear plants, and protect its valuable nuclear export business.

Mr. Mullick has a broad range of experience providing counsel to companies on export control matters administered by the Bureau of Industry and Security (BIS) under the Export Administration Regulations (EAR), the Directorate of Defense Trade Controls (DDTC) under the International Traffic in Arms Regulations (ITAR), the Department of Energy's rules on nuclear exports under Part 810, as well as economic sanctions administered by the Office of Foreign Assets Control (OFAC).

We also help governments strengthen their trade relationship with the US, which can involve securing free trade agreements, bilateral investment treaties or nuclear export agreements, as well as qualifying for and maintaining preferential trade benefits.

Binds to the Rev Response Element (RRE) within unspliced and partially spliced transcripts to facilitate nuclear export.

But nuclear exports are tightly controlled because the technology is potentially so dangerous.

Next, Grima looked at cell death in cultured neurons with a healthy or a mutant form of Huntingtin, or with a mutant form of Huntingtin that was treated with small amounts of an experimental drug called KPT - 350, one that prevents a nuclear export protein, Exportin - 1, from shuttling proteins and RNA out of the nucleus.

Those treated with the nuclear export blocking drug had improved survival, with only about 22 percent of the cells die off.

The suppression of FOXO3 by the combination of HCV and alcohol is attributed in part to nuclear export and a decreased protein half - life that does not occur with either HCV or alcohol alone.

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.

In addition, others (36) have shown that inhibition of exportin 1, a nuclear export receptor, can lead to accumulation of p70S6K in the nucleus of kidney cells.

He advises clients regarding commercial issues relating to nuclear power plants and other nuclear assets, nuclear export controls, certain government contracts matters, NRC's review of license transfers, decommissioning funding issues, foreign ownership, control or domination (FOCD) issues, nuclear export controls, and the unique insurance and liability issues associated with the ownership and operation of nuclear assets.