Sentences with phrase «nuclear gene expression»

Nuclear gene expression changes due to mitochondrial dysfunction in ARPE - 19 cells: implications for age - related macular degeneration.

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

Not exact matches

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

These new piRNAs bind to a nuclear PIWI protein to repress the expression of the jumping gene in the nucleus.

Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type.

Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

Decreased nuclear HDAC activity results in global H3 acetylation, creating a permissive environment for cocaine - induced gene expression.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

Therapeutic drugs can also be made to fit these pockets, switching the nuclear receptor on or off to alter gene expression.

Regulated expression of a gene encoding a nuclear factor, IRF - 1, that specifically binds to IFN - β gene regulatory elements.

Patricia Heyn (Neugebauer, MPG)-- «Nuclear architecture and gene expression during early zebrafish development» (2013)

The Nurr1 Activator 1, 1 - Bis (3 ′ - Indolyl)-1 -(p - Chlorophenyl) Methane Blocks Inflammatory Gene Expression in BV - 2 Microglial Cells by Inhibiting Nuclear Factor κB.

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].

14: Boominathan A, Vanhoozer S, Basisty N, Powers K, Crampton AL, Wang X, Friedricks N, Schilling B, Brand MD, O'Connor MS. Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant.

Our gene expression and embryo development data suggest that FSH and LH may not affect oocyte nuclear and cytoplasmic maturation directly.

Using high - resolution quantitative approaches, her laboratory investigates how gene expression is regulated from both the nuclear and mitochondrial genomes.

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression.

We are investigating how nuclear proteins regulate the expression of organelle genes.

Age - induced accumulation of nuclear DNA damage, decline in mitochondrial function and alterations in gene expression have been thought to contribute to aging.

Other types of RNA play important roles in regulating gene expression (microRNAs), RNA processing by the spliceosome (small nuclear RNAs or snRNA), and protein translation (tRNAs).

We also demonstrate that ACTB haploinsufficiency leads to reduced cell proliferation, altered expression of cell - cycle genes, and decreased amounts of nuclear, but not cytoplasmic, β - actin.

The aryl hydrocarbon receptor (AHR) is a widely expressed nuclear receptor that senses environmental stimuli and modulates target gene expression.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.

For example, a recent study developed a cell proliferation signature that consists of the top 1 % genes whose expression is most positively correlated with that of proliferating cell nuclear antigen (PCNA).

The vitamin A — RXR - alpha complex «dimerizes» with these other nuclear receptors, forming a new complex that acts as a transcription factor to turn on gene expression.

Curcumin activates PPAR (peroxisome proliferator - activator receptor) which is a group of key nuclear proteins that regulate gene expression and modulate sugar uptake and utilization in the bloodstream.

Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function