Sentences with phrase «nuclear genes from»

They sequenced 10 nuclear genes from 89 modern species of cichlids and 69 other fish to come up with dates when cichlids diverged from their fishy relatives.

Not exact matches

And the same is going to be true now as public interest shifts from nuclear physics to molecular biology, from the splitting of atoms to the splicing of genes.

The mix of nuclear genes would come from the archaeal guest and later from the mitochondrion, which forfeited parts of its genome to the nucleus over time.

Pääbo is seeking evidence of early gene swapping by trying to get nuclear DNA from the HST Neandertal and others.

Dart - biopsy samples from 195 free - ranging African elephants in 21 populations were examined for DNA sequence variation in four nuclear genes (1732 base pairs).

At the same time, coauthor Peter Adams, from the University of Glasgow, published a previous study on the breakdown of the nuclear lamina in which he observed a peculiar protrusion, or blebbing, of the nuclear envelope into the cytoplasm, and these blebs contained DNA, nuclear lamina proteins, and chromatin (the nuclear structures in which genes reside).

Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine (Centro Andaluz de Biología Molecular y Medicina Regenerativa — Cabimer) have discovered that in eukaryotic cells the proximity of the genes to the nuclear pores, which are found in the nuclear membrane, contributes to maintaining the integrity of the genome.

From one collection of mutations of protein coding genes, they identified the nuclear components Mlp1 and Mlp2 of the macrocomplex that form the nuclear pores, preserved in all the eukaryotes, including the human ones.

This marks the first time a particular gene was sequenced from a Neandertal's nuclear DNA.

They then amplified and sequenced two nuclear and three mitochondrial genes from each tissue, amounting to nearly 5,000 base pairs of DNA, from over 120 individuals.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

He accomplished that with the help of a virus different from the retroviruses used initially: an adenovirus that brings the genes into a cell's nuclear area but doesn't become part of the cell's DNA; it disappears after it expresses the reprogramming genes.

The HIV genes that do remain are very important for viral production: Gag (structural precursor protein), Pol (polymerase), Tat (viral transactivator for transcriptional activation from the 5» LTR) and Rev (facilitates nuclear export of transcripts).

On the other hand, antibody genes are actively transcribed and recombined in developing B - cells, and therefore positioned in the nuclear interior, far away from the periphery.

The researchers found that patients from MODY3 families had one of several different mutations in the gene for hepatocyte nuclear factor 1 alpha (HNF -1-alpha) but healthy subjects had normal copies of the gene.

Piroska Szabó of the Van Andel Research Institute in Grand Rapids, Michigan, was once excited to think she'd discovered a new gene that expressed only the maternal allele — until she realized that the RNA sequences she was looking at were from a gene that had been misannotated as a nuclear gene, explaining the maternal - only inheritance.

Sequences for 54 nuclear genes were taken from Perelman et al.'s [12] nexus file with modifications to eliminate problems with probable contaminants and misidentified sequences (Table S2); sequences for 15 additional nuclear genes (ABO, CXCR4, CXCR5, Epsilon globin, FGA, IRBP intron 1, IRBP intron 3, MC1R, NRAMP, PRNP, VWF intron 11) were obtained from GenBank; and new sequences (JX856181 - JX856283, JX869897 - JX869930) for exons of four nuclear genes (GHR, IRBP, VWF, TTN) were combined with previously published GenBank sequences for these loci.

It will be important in future studies to improve both gene and taxon sampling for primate species, to construct separate trees based on mitochondrial and nuclear loci, and to tease apart differences that arise from incomplete lineage sorting versus other types of discordance including introgression and sex - biased dispersal [75]--[77].

Using high - resolution quantitative approaches, her laboratory investigates how gene expression is regulated from both the nuclear and mitochondrial genomes.

Here, we generate a robust molecular phylogeny for 70 primate genera and 367 primate species based on a concatenation of 69 nuclear gene segments and ten mitochondrial gene sequences, most of which were extracted from GenBank.

This phylogeny combines a robust framework for primate families and most genera based on nuclear genes with the expanded taxonomic coverage for genera and species that results from the inclusion of mitochondrial DNA sequences.

This unrooted tree is inferred from 229 concatenated nuclear protein - coding genes with 44,616 amino acids using Bayesian inference.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Inserting it into the nuclear genome helps to protect the gene from oxidative damage, while our tagging system will help guide the functional protein into the mitochondria where it is needed.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.

Superman (Christopher Reeve) tries to save the world from nuclear destruction at the hands of Lex Luthor (Gene Hackman) in this action film featuring the man of steel.

In the absence of a population suitable for GWAS, we utilized genome - wide SNP profiles from a nuclear family to evaluate inheritance patterns in chromosomal regions harboring all 18 candidate genes.