Sentences with phrase «nuclear genes in»

The researchers detected some left - behind nuclear genes in supposed ancients, such as Giardia, Trichomonas and some microsporidia.

Mitochondrial fingerprinting is normally used when the genetic material in a sample is degraded, for while there are only two copies of each nuclear gene in a cell, there are often hundreds of copies of mitochondrial DNA (mtDNA).

Not exact matches

The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.

This study found that the interaction between these genomes and the implications on energy production is strong enough that the mitochondrial genome can alter which version of a gene is present in the nuclear genome.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

Besides the low efficiency of cloning — just 1.7 per cent of embryos came to term — another challenge to creating transgenic dogs is controlling where in the nuclear DNA a foreign gene lands.

«To be true genetic or germline therapy, you must modify genes in nuclear DNA.»

These new piRNAs bind to a nuclear PIWI protein to repress the expression of the jumping gene in the nucleus.

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type.

Dart - biopsy samples from 195 free - ranging African elephants in 21 populations were examined for DNA sequence variation in four nuclear genes (1732 base pairs).

The researchers compared thousands of genes in the rattlesnakes» nuclear DNA to study genomic differentiation between the two lineages.

Further genetic information such as nuclear genes and morphological relationships should reveal genetic similarities and crossbreeding process in future investigations.

At the same time, coauthor Peter Adams, from the University of Glasgow, published a previous study on the breakdown of the nuclear lamina in which he observed a peculiar protrusion, or blebbing, of the nuclear envelope into the cytoplasm, and these blebs contained DNA, nuclear lamina proteins, and chromatin (the nuclear structures in which genes reside).

Another illustrative finding was that the sirt1 nuclear gene, which is an important but controversial gene in aging research, Rand said, shows different effects on longevity given different mitochondrial genomes.

The team knocked out the gene for a protein called nuclear receptor corepressor 1 (NCoR1) in the muscles of mice.

Researchers are now finding hints that cells» efforts to keep nuclear and mitochondrial genes in sync could play a major role in evolution.

As subpopulations moved into isolated areas, how did they remain isolated over a long enough time for new species - defining traits to arise in nuclear genes and become enriched by natural selection to permit speciation?

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

Results for different genomic partitions, methods, and data types are consistent with or contradict clades in our TENT ExaML, TENT MP - EST *, and exon - only trees and previous studies of morphology (15), DNA - DNA hybridization (24), mitochondrial genes (14), and nuclear genes (17).

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

Decreased nuclear HDAC activity results in global H3 acetylation, creating a permissive environment for cocaine - induced gene expression.

Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine (Centro Andaluz de Biología Molecular y Medicina Regenerativa — Cabimer) have discovered that in eukaryotic cells the proximity of the genes to the nuclear pores, which are found in the nuclear membrane, contributes to maintaining the integrity of the genome.

To further explore nuclear transport's role in Huntington's disease, Grima took lab - grown mouse neurons and used chemical switches to a) turn on both an additional healthy copy of the RanGAP1 gene and a mutant version of Huntingtin; b) just turn on the mutant Huntingtin; or c) just turn on a healthy version of Huntingtin.

From one collection of mutations of protein coding genes, they identified the nuclear components Mlp1 and Mlp2 of the macrocomplex that form the nuclear pores, preserved in all the eukaryotes, including the human ones.

Or consider the nuclear genes of the cells of advanced organisms (eukaryotes): At some early point in their evolution, these cells gained the help of the genes of a parasite or symbiont that became the mitochondrion, an organelle necessary for energy production.

The thread to follow here is that the invention of nuclear transfer technology — the means to move genes between cells and also backward in time — started the countdown to human reproductive cloning.

The samples were then analyzed with a technique called polymerase chain reaction (PCR), used to amplify specific nuclear «microsatellites» for statistically measuring gene flow between the different populations and subpopulations located in the western South Atlantic (Breeding Stock A) and the eastern South Atlantic and Indian Ocean populations (Breeding Stocks B and C, and the Arabian Sea humpback whale population, respectively).

A second paper in the same issue of Science describes the nuclear genes, thanks to work by more than 75 researchers.

Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.

For each, they tried to clone the gene and express it in a bacterium, purify and crystallize the protein, and determine its structure through x-ray crystallography or nuclear magnetic resonance spectroscopy.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

The branch uniting the fungi and animals is well - supported based on a number of molecular phylogenetic datasets, including the nuclear small subunit ribosomal RNA gene (Wainwright et al., 1993; Bruns et al. 1993), unique and shared sequence insertions in proteins such as elongation factor 1α (Baldauf and Palmer, 1993), entire mitochondrial genomes (Lang et al., 2002), and concatenated protein - coding genes (Steenkamp et al., 2006).

Synonymous and nonsynonymous rate variation in nuclear genes of mammals.

You are what you eat: a gene transfer ratchet could account for bacterial genes in eukaryotic nuclear genomes.

The protein binds to RNA in the nucleus to form «small nuclear ribonucleoproteins,» which help splice the messenger RNA of many other genes, in preparation for nuclear export and transcription.

Nuclear gene expression changes due to mitochondrial dysfunction in ARPE - 19 cells: implications for age - related macular degeneration.

The Nurr1 Activator 1, 1 - Bis (3 ′ - Indolyl)-1 -(p - Chlorophenyl) Methane Blocks Inflammatory Gene Expression in BV - 2 Microglial Cells by Inhibiting Nuclear Factor κB.

Many of the apparently missing genes are encoded in the nuclear genome of the host.

Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate - Early Genes.

The lead author, Karen Reddy, a postdoctoral fellow in the Singh laboratory, proposes that, such compartmentalization «implies the existence of DNA segments that encode for «nuclear addresses» acting like a nuclear zip code to direct or predispose genes to associate with specific regions within the nucleus.

Here we show variation between incompatible Culex strains in two Wolbachia ankyrin repeat - encoding genes associated with a prophage region, one of which is sex - specifically expressed in some strains, and also a direct effect of the host nuclear genome on CI rescue.

On the other hand, antibody genes are actively transcribed and recombined in developing B - cells, and therefore positioned in the nuclear interior, far away from the periphery.

However, the authors found no evidence for a role of Setd7 in histone methylation or as a partner of MyoD in MuSCs and instead, they discovered that Setd7 interacted with - catenin and modulated its methylation status to promote nuclear translocation and the transcription of Wnt - responsive myogenic genes.

The only plausible methods of repairing stochastic nuclear DNA damage look to be the aforementioned advanced molecular nanotechnology, something that lies some decades in the future, or major advances in gene therapy, to the point at which it could be cost - effective and safe to scan and conditionally alter the majority of genes in the majority of cells all at once.

The researchers found that patients from MODY3 families had one of several different mutations in the gene for hepatocyte nuclear factor 1 alpha (HNF -1-alpha) but healthy subjects had normal copies of the gene.

«In cells that don't produce antibodies, like fibroblasts or T - cells, these antibody genes are attached to the inner nuclear membrane and are not recombined or expressed,» said Singh.

«Several years ago, we and others described the correlation between nuclear positioning and gene activation,» said study author Harinder Singh, Louis Block Professor of Molecular Genetics and Cell Biology and an Investigator in the Howard Hughes Medical Institute at the University of Chicago.

Known key pathological mechanisms are related to defects in structural proteins, nuclear proteins, intermediate filaments and other cyoskeletal proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.

Piroska Szabó of the Van Andel Research Institute in Grand Rapids, Michigan, was once excited to think she'd discovered a new gene that expressed only the maternal allele — until she realized that the RNA sequences she was looking at were from a gene that had been misannotated as a nuclear gene, explaining the maternal - only inheritance.