Sentences with phrase «nuclear localization»
The phrase "nuclear localization" refers to the process of specific molecules or proteins being directed to the nucleus of a cell. They move from different parts of the cell and concentrate in the nucleus, which is considered the control center of the cell. This localization is important for various cellular functions and regulatory processes within the nucleus. Full definition
Together, our results suggest that the decreased expression or loss of nuclear localization of DDX3 may play a regulatory role in the formation of liver tumor and cutaneous SCC.
cancerres.aacrjournals.org
Block in nuclear localization of period protein by a second clock mutation, timeless.
Erik Muellers (Lindemann, TUD)-- «Prototype foamy virus gag nuclear localization and glycine - arginine box functions revised» (2011)
Total 4E - BP1 and p - 4E - BP1 was predominantly cytoplasmic, although additional nuclear localization was seen in a small subset of tumor cells.
Because DDX3 harbors a dominant nuclear localization in normal squamous cells and exerts a transactivation function on p21waf1 / cip1 promoter, presumably the inactivation of transcriptional modulation function of DDX3 through cytoplasmic mislocalization is relevant to the deregulation of cell growth in cancerous squamous cells.
Consistently, we observed nuclear localization of β - catenin in the more - lateral mesoderm only, and β - catenin overactivation converted the mesodermal midline toward a more lateral fate and position (fig.
The nuclear import of unphosphorylated STAT2 depended on its association with IRF - 9, which contained a constitutive nuclear localization signal (35).
Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA - binding domain and interaction with cytoplasmic retention factors
Simplet / Fam53b is required for Wnt signal transduction by regulating β - catenin nuclear localization.
More specifically, addition of the PI3K inhibitor LY294002 to the growth medium of mouse muscle cells produces enhanced nuclear localization of FOXO1 and increased MAFbx mRNA transcription (52, 53).
Decreased mTORC1 activation and subsequent decreases in muscle protein synthesis, coupled with increased FOXO nuclear localization, increased transcription of atrophy - related genes, with up - regulated caspase 3 activation and muscle protein ubiquitylation provide a possible mechanism contributing to skeletal muscle loss in response to periods of negative energy balance.
Prototype Foamy Virus (PFV) Gag nuclear localization - A novel pathway among retroviruses.
L. B. Vosshall et al., «Block in nuclear localization of period protein by a second clock mutation, timeless,» Science 263, 5153 (18 March 1994)
The predictors include «Online Mendelian Inheritance in Man» (OMIM, a list of genetically caused diseases), receptors, kinases, growth factors, transcription factors, tissue specific, plasma membrane localization, nuclear localization and conversation index.
Nuclear localization of KLF4 is associated with an aggressive phenotype in early - stage breast cancer
Bioinformatic analyses suggest that glycine - arginine and proline - arginine repeats could mimic the nuclear localization signals of these proteins and hence hijack nuclear import by overloading the nucleocytoplasmic transport system.
Plasma Membrane and Nuclear Localization of G Protein — coupled Receptor Kinase 6A.
Inhibits the activity of dimeric NF - kappa - B / REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals.
Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis.
Critically, the absence of dimerizer ligand in the target cell culture medium and the presence of a nuclear localization signal on the Cas9 endonuclease ensures that the complex dissociates from the red fluorescent protein and is transported to the nucleus.
Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice.
Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1 - dependent nuclear export.
In addition, a χ2 test was used to analyze the loss of nuclear localization in SCC specimens.
The nuclear localization of DDX3 is altered in SCC.
Additionally, an extensive loss of its nuclear localization was observed in cutaneous squamous cell carcinoma (SCC) compared with normal squamous cells.
FLPe's performance was further improved, by adding a nuclear localization sequence (SV40 Large T nuclear localization sequence) and expressing it from a CAGGs promoter.
This observation indicates that the loss of DDX3 nuclear localization is a frequent event in cutaneous SCC.
Whereas ABL1 has been reported to phosphorylate YAP1 in response to DNA damage (43), we found that ABL1 / ABL2 knockdown did not substantially alter YAP1 protein abundance (Fig. 7A), nuclear localization (fig.
Nuclear localization of the adenovirus DNA - binding protein: Requirement for two signals and complementation during viral infection