It will be one of the hardest forms of damage to repair via rejuvenation biotechnology; the only one that springs to mind as likely being even more difficult is the matter of damaged
nuclear pore proteins in long - lived cells, single molecules that might be as old as you are, doing the same job for an entire human life span.
«It will be one of the hardest forms of damage to repair via rejuvenation biotechnology; the only one that springs to mind as likely being even more difficult is the matter of damaged
nuclear pore proteins in long - lived cells»
The first in her family to earn a doctoral degree, Dr. Higa completed her thesis at the University of Utah in Oncological Sciences where she studied the roles of
nuclear pore proteins in nuclear export and nuclear envelope breakdown.
Grima also observed this same clumping of Huntingtin protein with RanGAP1 and
nuclear pore proteins to the wrong place in the cell in brain tissue and cultured brain cells derived from deceased patients with Huntington's disease.
It also clumped up in the same location as abnormal clumps of
nuclear pore proteins NUP88 and NUP62.
Not exact matches
Pores, composed of many different
proteins, the nucleoporins, cross the
nuclear envelope and monitor the heavy traffic of the molecules, which takes place between the nucleus and the cytoplasm of the cell.
According to the researchers, there is an average of 2000
nuclear pores per cell and each individual
nuclear pore consists of multiple copies of more than 30 different
proteins that each serve different functions.
From one collection of mutations of
protein coding genes, they identified the
nuclear components Mlp1 and Mlp2 of the macrocomplex that form the
nuclear pores, preserved in all the eukaryotes, including the human ones.
The jammed up
nuclear pores reopened, they report, and key
proteins once again moved into the nucleus.
Moreover,
proteins that rely on RanGAP for transportation into the nucleus don't flow through the
nuclear pores.
Thankfully, the research carried out identified a part of a
protein that if absent, would stop the HSV from entering through the
nuclear pore.