Sentences with phrase «nuclear pores»

Nuclear pores are tiny openings in the protective outer membrane of a cell's nucleus. They act like gatekeepers, allowing certain molecules and substances to enter or exit the nucleus, which is the control center of the cell. These pores help maintain the proper functioning of the cell by facilitating the transport of important materials. Full definition
The first in her family to earn a doctoral degree, Dr. Higa completed her thesis at the University of Utah in Oncological Sciences where she studied the roles of nuclear pore proteins in nuclear export and nuclear envelope breakdown.
It also clumped up in the same location as abnormal clumps of nuclear pore proteins NUP88 and NUP62.
RanGAP1 in turn helps move molecules through nuclear pores that serve as passageways in the nucleus, letting proteins and genetic material flow in and out of it.
Françoise Stutz, professor in the Faculty of Science at the University of Geneva (UNIGE), Switzerland, and her team have just discovered how nuclear pores also regulate the production speed of these DNA copies.
«It will be one of the hardest forms of damage to repair via rejuvenation biotechnology; the only one that springs to mind as likely being even more difficult is the matter of damaged nuclear pore proteins in long - lived cells»
It may be that nuclear pores on neurons and other types of brain cells like glia are constructed of different combinations of these proteins, some of which may be more or less critical in various neurodegenerative diseases.
Amo1 is not required for the microtubule loading of several factors affecting microtubule dynamics, and does not seem to be required for nuclear pore function.
We also determined the positions of various nuclear pore complex (NPC) components and directly resolved the ring - like structure of the NPC, combining stochastic super-resolution microscopy with single particle averaging.
The Ellenberg group studies cell division and nuclear organisation, focusing on chromosome organisation, the formation and segregation of mitotic chromosomes, as well as nuclear pore complex structure and assembly.
There, other glowing viruses already glide along protein rails to the nucleus, some entering through nuclear pores.
It will be one of the hardest forms of damage to repair via rejuvenation biotechnology; the only one that springs to mind as likely being even more difficult is the matter of damaged nuclear pore proteins in long - lived cells, single molecules that might be as old as you are, doing the same job for an entire human life span.
Molecular mechanisms and functions of SUMOylation; nuclear pore complexes and control of nucleocytoplasmic transport.
Compared with the nucleus of a normal fly neuron (left), one from a fly with a common ALS mutation has a damaged nuclear membrane (right) with clusters of nuclear pore protein (red) around its edges.
He was the first to measure the transition of a messenger RNA through the nuclear pore complex, determining that it was orders of magnitude faster than expected and that the rate - limiting steps in this process are at the nuclear and cytoplasmic surfaces.
After the yeast absorbs the sugar, the GAL1 gene is relocated to the nuclear pore.
The nuclear pores thus create an environment conducive to the efficient production of gene copies.
One of these compartments is none other than the nuclear pore, present in the hundreds or thousands, depending on the type of nucleus.
The transit between the nucleus and the cytoplasm takes place through the nuclear pores, genuine «customs agents» that monitor the import - export between these two compartments.
Nor do the multiple labs reporting results this week agree on exactly what plugs those nuclear pores and how the cells die.
For instance, levels of a nuclear pore protein called RanBP17 — whose decline is linked to nuclear transport defects that play a role in neurodegenerative diseases — were lower in the neurons derived from older patients.
Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine (Centro Andaluz de Biología Molecular y Medicina Regenerativa — Cabimer) have discovered that in eukaryotic cells the proximity of the genes to the nuclear pores, which are found in the nuclear membrane, contributes to maintaining the integrity of the genome.
The proximity and anchoring of the genes to the nuclear pores during transcription has been known of for more than a decade.
The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter.
According to the researchers, there is an average of 2000 nuclear pores per cell and each individual nuclear pore consists of multiple copies of more than 30 different proteins that each serve different functions.
Grima is currently working on answering this question using a new mouse model developed at Johns Hopkins that will allow him to isolate these nuclear pore proteins from different cell types in the mouse brain to identify whether these nuclear pore components are in fact different based on brain cell types and brain locations.
Additionally, he realized that other researchers previously showed that mutations in the nuclear pore protein NUP62 caused Huntington's disease - like pathology.
Grima also observed this same clumping of Huntingtin protein with RanGAP1 and nuclear pore proteins to the wrong place in the cell in brain tissue and cultured brain cells derived from deceased patients with Huntington's disease.
Because of such clues from others» research, Grima took on the task of investigating whether problems with nuclear transport and the nuclear pores also happened in neurons with Huntington's disease.
However, when the DNA in these mutations was again returned to the nuclear pore by means of a genetically - engineered artificial anchoring system, the hybrids and the instability were suppressed.
«In this work, we have seen that if DNA is located in the interior of the nucleus and removed from the nuclear pore, the formation of DNA - RNA hybrids are more likely.
From one collection of mutations of protein coding genes, they identified the nuclear components Mlp1 and Mlp2 of the macrocomplex that form the nuclear pores, preserved in all the eukaryotes, including the human ones.
NOX2, p22 < sup > phox and p47 < sup > phox are Targeted to the Nuclear Pore Complex in Ischemic Cardiomyocytes Colocalizing with Local Reactive Oxygen Species.
We recently indentified the mechanism for G2, dynein - dependent apical nuclear migration, which involves a Cdk1 - triggered recruitment of dynein to the nuclear pore complex (Baffet et al., Dev.
Thankfully, the research carried out identified a part of a protein that if absent, would stop the HSV from entering through the nuclear pore.
Just like various other viruses HSV has to make its way through the nuclear pore to the heart of the cell — the nucleus.
Profiling of a marker of the nuclear pore complex identifies several classes of phenotypic perturbations.
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