Because of such clues from others» research, Grima took on the task of investigating whether problems with nuclear transport and
the nuclear pores also happened in neurons with Huntington's disease.
Françoise Stutz, professor in the Faculty of Science at the University of Geneva (UNIGE), Switzerland, and her team have just discovered how
nuclear pores also regulate the production speed of these DNA copies.
Not exact matches
It
also clumped up in the same location as abnormal clumps of
nuclear pore proteins NUP88 and NUP62.
Grima
also observed this same clumping of Huntingtin protein with RanGAP1 and
nuclear pore proteins to the wrong place in the cell in brain tissue and cultured brain cells derived from deceased patients with Huntington's disease.
We
also determined the positions of various
nuclear pore complex (NPC) components and directly resolved the ring - like structure of the NPC, combining stochastic super-resolution microscopy with single particle averaging.