Dietary fibre modifications that are low in fat and glucose reduce the risk for AD by not only effecting cell membranes and nutrient sensing G coupled receptors but also by regulating number of
nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis.
by regulating number of
nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis.
Not exact matches
In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins
such as Ras,
nuclear lamins and insulin - like growth factor
receptors.
He uses the paradigm of
nuclear hormone
receptor activation / signaling and the contribution of this process to myeloid cell differentiation, function, and to diseases, involving these cells,
such as atherosclerosis, tissue regeneration, metabolic, and various inflammatory disorders, as his model systems.
To enable
such a system in plants, the re-designed
receptors need to be targeted extracellularly and we need to address eukaryotic processes that are not fully understood,
such as transmembrane signaling, signal - dependent
nuclear translocation, and other signaling complexities.