Sentences with phrase «nuclear translocation»
"Nuclear translocation" refers to the movement of a substance from outside the nucleus to inside the nucleus of a cell. It involves the substance crossing the nuclear membrane to reach the core of the cell, where important genetic material is stored. Full definition
(C) Absence of signal dependent nuclear translocation of a mutated PhoB - GFP in the synthetic signal transduction pathway.
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We find that stomodeal compression triggers Src42A - dependent nuclear translocation of Armadillo / beta - catenin, which is required for Twist mechanical induction in the stomodeum.
The stimulated nuclear translocation of signaling proteins, such as MAPKs, is a necessity for the initiation and regulation of their physiological functions.
A p38 / JNK nuclear translocation — blocking peptide may be therapeutic in various cancers and inflammation - associated diseases.
AIRE - induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH.
However, the authors found no evidence for a role of Setd7 in histone methylation or as a partner of MyoD in MuSCs and instead, they discovered that Setd7 interacted with - catenin and modulated its methylation status to promote nuclear translocation and the transcription of Wnt - responsive myogenic genes.
GFP fluorescence was diffuse both before and after treatment with the ligand, indicating no obvious nuclear translocation.
We then show that an adapted HK functions in plants by linking it to a transcriptional response through signal - dependent nuclear translocation of a bacterial response regulator [12], to produce a synthetic signal transduction system.
Lin, R., Heylbroeck, C., Pitha, P. M. & Hiscott, J. Virus - dependent phosphorylation of the IRF - 3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome - mediated degradation.
Transgenic lines, from left to right, are paired sets from lines containing all components but lacking the TNT receptor -LRB-- TNT receptor); lacking the chimeric histidine kinase -LRB-- Trg - PhoR); lacking the protein for nuclear translocation / transcriptional activation -LRB-- PhoB - VP64); with the phospho - relay disrupted (PhoBD53A - VP64).
Acting via the MyD88 adaptor and STAT1 protein phosphorylation, activated TLR4 results in nuclear translocation of the transcription factor NF - κB and subsequent mRNA expression of proinflammatory cytokines.
Together, these results support the use of the nuclear translocation of p38 and JNK as a novel drug target to treat various cancers and inflammation - induced diseases.
Previously, we determined that nuclear translocation of the MAPKs p38 and JNK involves binding to heterodimers comprising importin 3 and either importin 7 or importin 9.
In vivo analysis further suggested that this effect was mediated by PERY peptide — induced prevention of the nuclear translocation of p38 in macrophages.
The PERY peptide specifically blocked the interaction of p38 and JNK with the importins, restricted their nuclear translocation, and inhibited phosphorylation of their nuclear (but not cytoplasmic) substrates.
These results suggest that rel - related transcription factors, which are capable of cytosolic to nuclear translocation, may be held in the cytosol by interaction with related cytoplasmic anchor molecules.
It contains motifs that are responsible for dimerization, nuclear translocation and binding to NF - κB - binding motifs that are present in DNA.
Plants containing the same gene circuit but with the phospho - accepting Asp53 mutated (PhoBD53A - GFP) did not show ligand - dependent nuclear translocation (Figure 2C), indicating that the phospho - relay is required for ligand - mediated nuclear translocation of PhoB in planta.
To enable such a system in plants, the re-designed receptors need to be targeted extracellularly and we need to address eukaryotic processes that are not fully understood, such as transmembrane signaling, signal - dependent nuclear translocation, and other signaling complexities.
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation
Inhibition of pSTAT 1 Nuclear Translocation and Antiviral Protein Expression in Human Brain Vascular Adventitial Fibroblasts Infected with Varicella Zoster Virus J Virol.
Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells.