Sentences with phrase «nuclear translocation of»

Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells.

To examine the functional role of Smad1 and Smad5 in GDF5 - induced neurite length, primary cultures were transfected by microporation with siRNAs targeting the co-Smad4 (required for nuclear translocation of Smad1 / 5 transcriptional complex [33]-RRB- or the Smad1 and Smad5 effectors proteins, which are known targets of miR - 181a (Table 2).

We then show that an adapted HK functions in plants by linking it to a transcriptional response through signal - dependent nuclear translocation of a bacterial response regulator [12], to produce a synthetic signal transduction system.

The Wiskott - Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF - $ ąppa $ B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement.

Fenofibrate - induced nuclear translocation of FoxO3A triggers Bim - mediated apoptosis in glioblastoma cells in vitro.

In vivo analysis further suggested that this effect was mediated by PERY peptide — induced prevention of the nuclear translocation of p38 in macrophages.

Previously, we determined that nuclear translocation of the MAPKs p38 and JNK involves binding to heterodimers comprising importin 3 and either importin 7 or importin 9.

Together, these results support the use of the nuclear translocation of p38 and JNK as a novel drug target to treat various cancers and inflammation - induced diseases.

Not exact matches

The PERY peptide specifically blocked the interaction of p38 and JNK with the importins, restricted their nuclear translocation, and inhibited phosphorylation of their nuclear (but not cytoplasmic) substrates.

Lin, R., Heylbroeck, C., Pitha, P. M. & Hiscott, J. Virus - dependent phosphorylation of the IRF - 3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome - mediated degradation.

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder.

However, the authors found no evidence for a role of Setd7 in histone methylation or as a partner of MyoD in MuSCs and instead, they discovered that Setd7 interacted with - catenin and modulated its methylation status to promote nuclear translocation and the transcription of Wnt - responsive myogenic genes.

Inhibition of pSTAT 1 Nuclear Translocation and Antiviral Protein Expression in Human Brain Vascular Adventitial Fibroblasts Infected with Varicella Zoster Virus J Virol.