Sentences with phrase «nuclease models»

Moreover, it was confirmed that, compared to previous nuclease models, cytotoxicity is significantly reduced by modifying the DNA without cutting.

In the nuclease model (left) mainly insertion and deletion are induced but in the deaminase model only point mutation is induced.

Not exact matches

Genetically - modified mouse models: pros and cons of nucleases - based technologies.

The adaptation of xenopus model to new technologies such as customized nucleases and automated screening tools, enables a wider use of the amphibian model.

2) If ES cell clones are not available from the IKMC / IMPC resource, mouse models will be generated using genome editing approaches such as CRISPR / Cas9 nuclease technology (on C57BL / 6N genetic background only) and may cover constitutive knock - outs or point mutations.

Genetic Engineering and Model Validation: engineering and generation of customised genetically modified mouse models, generation of genetically modified ES cells, genotyping, analysis of gene expression, model validation by molecular analysis, CRISPR / Cas9 nucleases technModel Validation: engineering and generation of customised genetically modified mouse models, generation of genetically modified ES cells, genotyping, analysis of gene expression, model validation by molecular analysis, CRISPR / Cas9 nucleases technmodel validation by molecular analysis, CRISPR / Cas9 nucleases technology

Speakers will discuss applications of patient - specific and disease - specific stem cell lines, including gene repair (via tools such as the Cas9 nuclease), disease modeling, drug screening, and regenerative medicine.