Roger Williams, Burke's postdoctoral advisor in the division of protein and
nucleic acid chemistry at the Medical Research Council Laboratory of Molecular Biology, called Burke «simply one of the best postdoctoral researchers with whom I have worked in the 25 years that I have been a group leader in the Laboratory of Molecular Biology in Cambridge, UK.
DNA repair is a hugely important topic and these three were the first to describe the repair mechanisms,» Thomas Carell, who studies
nucleic acid chemistry at Ludwig Maximilians University in Munich, told Science.
Not exact matches
According to one of his analogies: just as the sequence of letters on a page is extraneous to the
chemistry of ink and paper, so the sequence of
nucleic acids in the DNA molecule (which, when translated, determines the shape of an organism and its specific characteristics) is extraneous to the chemical forces operative in the genetic process.
Still is it not possible that the specific sequence of base - pairs in a DNA molecule is extraneous to the
chemistry which bonds the
nucleic acids to one another?
So we must ask whether
chemistry (or any physical science) can specify the overall sequence of
nucleic acids that determines the kinds and shapes of organisms existing in the biosphere.
So that has made us look again at the
chemistry of replication and start to explore a wider range of
nucleic acids.
Attendees at the astrobiology meeting in Arizona showcased an assortment of high - tech devices for next - generation exploration, ranging from microfluidic «life analyzers» and integrated
nucleic acid extractors for studying «Martian metagenomics» to exquisitely sensitive, miniaturized organic
chemistry labs for spotting tantalizing carbon compounds and minerals at microscopic scales.
He won two Nobel Prizes for
chemistry, but we claim him for molecular biology because the methods he developed for sequencing proteins and
nucleic acids provide the basis for much of what we do today.
Joint winner of the 1980
chemistry prize with Walter Gilbert for his «contributions concerning the determination of base sequences in
nucleic acids» and winner of the 1958
chemistry prize «for his work on the structure of proteins, especially that of insulin.»
Winner of the 1982
chemistry prize «for his development of crystallographic electron microscopy and his structural elucidation of biologically important
nucleic acid - protein complexes.»
Mirkin is director of the research group that invented the
chemistry for conjugating DNA and nanoparticles and a pioneer of the concept of programmable colloidal crystallization with
nucleic acids.
So that made us look again at the
chemistry of replication and start to explore a wider range of
nucleic acids.