Sentences with phrase «nucleic acid molecules»

Preparation and global prosecution of patent applications directed to diagnostic and therapeutic products including antibodies, gene therapies, vaccines, stem cells, pharmaceutical formulations, nanotechnology, nucleic acid molecules, biologics, medical devices, mouse platforms for antibody development, and methods of treating diseases.

The CRISPR system is made up of two components: a protein called Cas9 and a guide RNA, a string of nucleic acid molecules with a certain genetic code.

Ronald W. Davis, Ph.D., Stanford University, Stanford, Calif. $ 450,000 (2 years) «Single Molecule Nucleic Acid Detection with Nanopipettes» This group takes a stepwise approach to single nucleic acid molecule detection, using the nanoscale pore in a pulled glass pipette to measure single DNA molecules with attached nanoparticles.

Not exact matches

According to one of his analogies: just as the sequence of letters on a page is extraneous to the chemistry of ink and paper, so the sequence of nucleic acids in the DNA molecule (which, when translated, determines the shape of an organism and its specific characteristics) is extraneous to the chemical forces operative in the genetic process.

Still is it not possible that the specific sequence of base - pairs in a DNA molecule is extraneous to the chemistry which bonds the nucleic acids to one another?

Out of the Gordon Conference on nucleic acids in the summer of 1973 came an open letter to Science; the establishment (in October 1974) by the National Institutes of Health of the Recombinant DNA Molecule Program Advisory Committee; and in February 1975 the now - famous international conference at the Asilomar Conference Center in California, where a reluctant decision was made by scientists to declare a temporary moratorium on certain kinds of DNA research.

The shortest chain of nucleic acids capable of replicating itself consists of only 6 molecules.

The apparent gap between nonliving and living has now been bridged by nucleic acids, a class of polymeric organic molecules composed of a succession of small units (nucleotides) of four sorts, the order of which determines an indefinitely large number of different specificities.

They are the principal component, other than water, of all living forms, but the nucleic acids alone have the remarkable property of being capable of duplicating their patterns, whatever they may be, from small molecules in their medium.

The four major classifications of biological molecules are proteins, carbohydrates, lipids (fats), and nucleic acids (but we won't be dealing with these today).

«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of nucleic acid that binds a specific sequence in the gene.»

It asserted that bacterial death probably results from chlorine attacking a variety of bacterial molecules or targets, including enzymes, nucleic acids and membrane lipids.

Cells were stained with the actin binding molecule, phalloidin (red) and nucleic acid stain, DAPI (blue).

While the bulk of CureVac's prize money will go to basic molecular immunology research, Hoerr says he also wants to set aside a portion to pay tribute to Miescher, the biologist from Switzerland who identified nucleic acids, a family of key biological molecules that includes DNA and RNA, in his lab in Tübingen.

A new nucleic acid sequencing platform, the Sequel System, provides higher throughput, more scalability, a reduced footprint, and lower sequencing project costs compared to the PacBio RS II System, while maintaining the existing benefits of single molecule, real - time (SMRT) technology.

Nucleic acids in the purified sample bind to those on the array, producing a signal — typically a fluorescent molecule.

Led by Dr. Peter Glazer, chair of therapeutic radiology, Dr. Mark Saltzman, chair of biomedical engineering, and Dr. Marie Egan, professor of pediatrics and of cellular and molecular physiology, the collaborative team used synthetic molecules similar to DNA — called peptide nucleic acids, or PNAs — as well as donor DNA, to edit the genetic defect.

GNA (glycol nucleic acid) is even simpler than TNA, with just three carbon atoms in its backbone, yet can still form helical molecules, much like DNA (The Journal of Organic Chemistry, DOI: 10.1021 / jo201469b).

This goo links molecules together when heated, stabilizing proteins and nucleic acids to maintain the integrity of the tissue.

«We've shown that these oviductosomes are carrying critical molecules that include not only proteins, but also nucleic acids such as RNA and also lipids,» DeLeon says.

The origin of life is not the same as the origin of its constituent building blocks, but laboratory studies on the linking of amino acids into molecules resembling proteins and on the linking of nucleotides into molecules resembling nucleic acids are progressing well.

We know that the master molecules of living organisms on the earth are the proteins and the nucleic acids.

Even the simplest life forms incorporate two amazingly complex types of organic molecules: proteins and nucleic acids.

He has manufactured intricate molecular rings containing carbon, nitrogen, and hydrogen; fatty - acid - like molecules that look and behave like the membranes protecting living cells; and nucleic acids or nucleotides, the primary components of RNA and DNA.

Like infinitesimally small Lego blocks, the nucleic acids that make up RNA connect to each other in very specific ways, which force RNA molecules to twist and loop into a variety of complicated 3D structures.

The technique has been an invaluable tool for investigating the structure and function of a broad range of biologically important molecules, including drugs, vitamins, proteins and nucleic acids like DNA.

Nitrogen is a key constituent of biological molecules such as amino acids and nucleic acids.

Optical imaging and spectroscopy, advanced optical imaging techniques in particular super-resolution fluorescence microscopy, optical physics, nanotechnology, single - molecule biophysics and macromolecular biochemistry, single - molecule imaging, gene expression, computational modeling, single - molecule (force) spectroscopy, biomolecular engineering, nucleic acid nanotechnology

Our cells depend on thousands of proteins and nucleic acids that function as tiny machines: molecules that build, fold, cut, destroy, and transport all of the molecules essential for life.

Nucleic acids are not only key molecules for the storage, replication and transcription of genetic information, but also serve as enzymes or regulators of a number of cell processes.

Large - scale and effective studies of biological molecules with a different structural basis such as proteins, nucleic acids, carbohydrates, lipids and numerous metabolites (including e.g. fatty acids, amino acids, purines, pyrimidines or steroids) is currently highly attractive because of the availability of modern instruments and tools for both separation and analysis (2 - D chromatographs, capillary electrophoresis systems, microfluidics, mass spectrometers, powerful NMR spectrometers, DNA / RNA arrays and others).

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

DNA is one of a class of molecules called nucleic acids.

DNA (DeoxyriboNucleic Acid) a molecule composed of two chains of nucleic acid bases held together by hydrogen bonds in a pattern resembling a flexible twisted ladAcid) a molecule composed of two chains of nucleic acid bases held together by hydrogen bonds in a pattern resembling a flexible twisted ladacid bases held together by hydrogen bonds in a pattern resembling a flexible twisted ladder.

As noted above, existing cancer vaccines that use dendritic cells require extracting cells from a patient's blood, treating them with an engineered protein or nucleic acid that combines tumor antigens with immune - stimulating molecules, and returning the activated dendritic cells to the patient.

Small molecule a low molecular weight (usually less than 500 Daltons) organic compound that can bind to and alter the activity or function of proteins, nucleic acids, or polysaccharides.

Additional «- omics» data streams include: transcriptomics, the pattern of RNA synthesis from DNA; proteomics, the distribution of proteins in cells; interactomics, the patterns of protein - protein and protein — nucleic acid interactions; and metabolomics, the nature and traffic patterns of transformations of small molecules by the biochemical pathways active in cells.

Intron a nucleic acid sequence that is NOT present in the final RNA molecule after the splicing process edits the precursor RNA molecule (pre-mRNA); see Exon.

Led by Dr. Peter Glazer, chair of therapeutic radiology, Mark Saltzman, chair of biomedical engineering, and Dr. Marie Egan, professor of pediatrics and of cellular and molecular physiology, the collaborative team used synthetic molecules similar to DNA — called peptide nucleic acids, or PNAs — as well as donor DNA, to edit the genetic defect.

The blueprint for life is a chain of nucleic acids formed into DNA molecules.

Particular expertise in fields relating to antibody therapeutics and formats, nucleic acid therapeutics, various small molecule therapeutics including covalent inhibitors, and vaccines.