Sentences with phrase «nucleic acid sequences»

In their report receiving advance online release in Nature, the investigators describe evolved versions of the DNA - cutting Cas9 enzyme that are able to recognize a different range of nucleic acid sequences than is possible with the naturally occurring form of Cas9 that has been used to date.

One well - accepted effort compares the nucleic acid sequences that code for ribosomal RNA and a few proteins in many different organisms.

And a new prototype device can display a fluorescent letter in the presence of nucleic acid sequences from the Ebola virus or the closely - related Marburg virus: «E» for Ebola or «M» for Marburg.

This blockchain manager would «compute a cryptographic hash» of a given «nucleic acid sequence» and «use» it as PoW before transmitting the attendant «new block... to the other nodes in [the] blockchain system.»

The more nucleic acids the sequences have in common, the more closely related two cultivars are.

A new nucleic acid sequencing platform, the Sequel System, provides higher throughput, more scalability, a reduced footprint, and lower sequencing project costs compared to the PacBio RS II System, while maintaining the existing benefits of single molecule, real - time (SMRT) technology.

To try to block elastase, biochemist Drew Smith of NeXstar Pharmaceuticals in Boulder, Colorado, earlier this year synthesized a nucleic acid sequence called an aptamer, which is designed for its shape.

Researchers have argued for decades whether these anchors have their own «genome,» and if so, whether its nucleic acid sequence is DNA or RNA.

The predicted molecular weight of serotonin transporter based on its nucleic acid sequence is 67,815.

All we need to know is the nucleic acid sequence and an antigen to identify specific antibodies,» Malamud said.

Sanger sequencing methods represent the most popular in a range of «first - generation» nucleic acid sequencing technologies.

«It involves much more than a certain nucleic acid sequence of DNA.»

Here we present fCCAC, an application of functional canonical correlation analysis to assess covariance of nucleic acid sequencing datasets such as chromatin immunoprecipitation followed by deep sequencing (ChIP - seq).

In 1999 the nucleic acid sequence archives contained a total of 3.5 billion nucleotides, slightly more than the length of a single human genome; a decade later they contained more than 283 billion nucleotides, the length of about 95 human genomes.

Intron a nucleic acid sequence that is NOT present in the final RNA molecule after the splicing process edits the precursor RNA molecule (pre-mRNA); see Exon.

The U.S. Supreme Court held that cDNA is eligible for patenting because it has a different nucleic acid sequence than the naturally occurring gene.

Not exact matches

Says Roberts: «He quickly figured out that if Illumina was successful, it would need more than the world's supply of oligonucleotides» — the short snippets of nucleic acid that are designed to pair up with specific genetic sequences, and which are critical for DNA or RNA analysis.

According to one of his analogies: just as the sequence of letters on a page is extraneous to the chemistry of ink and paper, so the sequence of nucleic acids in the DNA molecule (which, when translated, determines the shape of an organism and its specific characteristics) is extraneous to the chemical forces operative in the genetic process.

Still is it not possible that the specific sequence of base - pairs in a DNA molecule is extraneous to the chemistry which bonds the nucleic acids to one another?

So we must ask whether chemistry (or any physical science) can specify the overall sequence of nucleic acids that determines the kinds and shapes of organisms existing in the biosphere.

I have followed Polanyi's contention that there are organizational principles operative in the universe which formatively influence the specific sequences of nucleic acids in DNA, and with Sheldrake I have postulated the existence of morphogenetic fields which canalize the processes of growth and development in organisms.

«It's difficult to make contrived samples behave like actual cell - free nucleic acids, so that's been quite a challenge,» says Kelli Bramlett, director of R&D in clinical sequencing and oncology at Thermo Fisher Scientific in Waltham, Massachusetts.

«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of nucleic acid that binds a specific sequence in the gene.»

To start, she used a cotton swab to get a sample of cells from her cheek, boiled them in a test tube in her kitchen to free the DNA, then added primers, nucleic acids that mark the part of the sequence.

Using a combination of old - fashioned clinical observation and modern biochemical analysis, he has shown that a person's appetite and their eating behavior can be linked to specific genes — and that even a tiny defect such as the absence of a single nucleic acid in a sequence of DNA can lead to runaway weight gain.

By the time he obtained his master's degree, new research suggested «that there was a system in the plant... able to recognize foreign nucleic acids and deal with them... in a sequence - specific manner,» Voinnet says.

Nucleic acid and protein sequences, as well as three - dimensional structures of proteins, are frequently the objects of study, but gene expression as well as the simulation of pathways and biochemical networks are attracting more and more attention.

MicroRNAs are short bits of nucleic acid — the material of DNA and RNA — that can bind to messenger RNAs that code for protein because they have a complementary sequence of A, U, C and G.

He won two Nobel Prizes for chemistry, but we claim him for molecular biology because the methods he developed for sequencing proteins and nucleic acids provide the basis for much of what we do today.

Joint winner of the 1980 chemistry prize with Walter Gilbert for his «contributions concerning the determination of base sequences in nucleic acids» and winner of the 1958 chemistry prize «for his work on the structure of proteins, especially that of insulin.»

Extracted nucleic acid was amplified using a random PCR method to generate cDNA libraries for Virochip and deep sequencing analyses as previously described [18], [21].

Modern molecular technologies (genomics and other omics), through comparing nucleic acid and amino acid sequences across living species, are enabling the identification of genetic components and patterns stingily conserved by evolution, from those in which times of evolutionary branching of the tree of life can be inferred.

Over the past decade due to the deep - sequencing technologies, we have studied the characterization of nucleic acid alterations in a wide range of cancers generating a large body of information on how cancer develops and evolves.

In the 11 years before joining the CNAG he worked at the Centre National de Génotypage of the Commissariat à l'Energie Atomique in Evry, France, first as Head of Technology Development and later as Associate Director under Prof. Mark Lathrop.His research interests are high - throughput nucleic acid analysis, sequencing, SNP genotyping, genomics, genetics, nucleic acid and protein analysis methods (molecular biological techniques and chemical modification), implementation of methods, automation and analysis.

He'd like a way to perform single - cell analysis using microarrays, instead of full sequencing, but chip - based bisulfite methods require more nucleic acid — about a microgram — than one cell can provide.

Stepwise synthesis of a nucleic acid to determine nucleotide sequences; inspired the DNA sequencing technique by F.Sanger (Sanger, Nobel Prize Lecture 2004).

However, being a complex multistep process, cancer cytogenetics are broadened to «cytogenomics,» with complementary resources on: general databases (nucleic acid and protein sequences databases; cartography browsers: GenBank, RefSeq, UCSC, Ensembl, UniProtKB, and Entrez Gene), cancer genomic portals associated with recent international integrated programs, such as TCGA or ICGC, other fusion genes databases, array CGH databases, copy number variation databases, and mutation databases.

In addition to Orgel and Ghadiri, authors on the paper, entitled «Self - Assembling Sequence - Adaptive Peptide Nucleic Acids,» are Yasuvuki Ura, John Beierle, and Luke Leman, all from The Scripps Research Institute.

His current research focuses on chemical evolution of sequence - defined carriers for drugs, proteins and therapeutic nucleic acids, with a medical focus on tumor - targeted therapies.

The classic data of bioinformatics include DNA sequences of genes or full genomes; amino acid sequences of proteins; and three - dimensional structures of proteins, nucleic acids and protein — nucleic acid complexes.

FLT3 TKD mutations are caused by nucleic acid substitutions and / or deletions that result in a change in the amino acid sequence in this highly conserved catalytic center.

We developed a way of getting siRNAs into epithelial cells by either mixing them with a transfection lipid used to introduce exogenous nucleic acids into cells in the lab or by adding a cholesterol tag to the end of the RNA sequence that allowed the RNA to be taken up into cells.

Our group seeks to investigate the use of chemically - modified nucleic acid aptamers, single stranded DNA or RNA sequences that specifically bind to a diverse variety of targets, in biosensing and catalysis.

Rearrangements in the mtDNA will be monitored by long extension - PCR (LX - PCR) and mtDNA point mutations will be analyzed by direct mtDNA sequencing and by Protein Nucleic Acid (PNA)- competitive PCR (PNA - PCR).