The immune system detects viruses when viral
nucleic acids bind protein receptors in immune cells.
Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of
nucleic acid binding proteins.
Characterization of
the nucleic acid binding region of adenovirus DNA binding protein by partial proteolysis and photochemical cross-linking
Not exact matches
One way to shut down the communication link is through a snippet of RNA called «antisense» — which
binds to the messenger RNA (a «sense» - making strip of
nucleic acids) that is transcribed by a given stretch of DNA.
«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of
nucleic acid that
binds a specific sequence in the gene.»
The new methods allowed them to catch proteins in the act of
binding to RNA, and also identify what part of the protein was in contact with the
nucleic acid.
Cells were stained with the actin
binding molecule, phalloidin (red) and
nucleic acid stain, DAPI (blue).
Nucleic acids in the purified sample
bind to those on the array, producing a signal — typically a fluorescent molecule.
MicroRNAs are short bits of
nucleic acid — the material of DNA and RNA — that can
bind to messenger RNAs that code for protein because they have a complementary sequence of A, U, C and G.
MicroRNAs are very short bits of
nucleic acid — the material of DNA and RNA — that can
bind to messenger RNAs that code for protein.
Antisense inhibitors are synthetic
nucleic acid drugs that can be designed to selectively
bind to messenger RNA from the targeted, disease - linked gene, and inactivate it.
These include membrane
bound proteins and
nucleic acids.
Therefore it is critical that
nucleic acid - sensing TLRs
bind their ligands and signal from the endocytic / phagocytic pathway.
Nuclear magnetic resonance structure of the
nucleic acid -
binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3.
Functions typically attributed to folded proteins occur inside, such as
binding and selectively concentrating single - stranded over double - stranded
nucleic acids.
Small molecule a low molecular weight (usually less than 500 Daltons) organic compound that can
bind to and alter the activity or function of proteins,
nucleic acids, or polysaccharides.
Our group seeks to investigate the use of chemically - modified
nucleic acid aptamers, single stranded DNA or RNA sequences that specifically
bind to a diverse variety of targets, in biosensing and catalysis.
Dr. Maria DeRosa's research examines a type of
nucleic acid called «aptamers» that can fold into 3D nanoscale shapes capable of
binding tightly to a specific molecular target.