Sentences with phrase «nucleic acids from»

Genetic and genomic analysis of nucleic acids from environmental samples has helped transform our perception of the subsurface as a major reservoir of microbial novelty.

«Recovering nucleic acids from ancient viruses is extremely difficult and plagued by contamination,» notes Angelique Corthals, a forensic anthropologist at the City University of New York in New York City, who was not involved in the study.

While James Watson and Francis Crick are considered the godfathers of DNA, Hoerr says, Miescher never received the credit he deserved for isolating and analyzing nucleic acids from pus cells.

Even after initial purification of the sample, liquid biopsies typically contain much more nucleic acid from healthy cells than from tumors.

The technique introduces modified segments of nucleic acid from the gene that produces the nicotine demethylase enzyme.

Not exact matches

They are the principal component, other than water, of all living forms, but the nucleic acids alone have the remarkable property of being capable of duplicating their patterns, whatever they may be, from small molecules in their medium.

A year earlier James Watson and Francis Crick had proposed their double - helix model of DNA, the nucleic acid that conveys genetic information from generation to generation in all organisms except certain viruses.

The field segregates into three major strategies: detecting free nucleic acids, isolating intact circulating tumor cells, and identifying extracellular vesicles from tumors.

Nucleic acids are also helping scientists to detect biomarkers, such as Abcam's Fireplex (formerly Firefly) particle technology, which profiles biomarker microRNAs (miRNAs) directly from biofluid samples, without RNA purification.

To start, she used a cotton swab to get a sample of cells from her cheek, boiled them in a test tube in her kitchen to free the DNA, then added primers, nucleic acids that mark the part of the sequence.

The findings, from the Emory / Johns Hopkins / Florida State team that showed this spring that neural progenitor cells are particularly vulnerable to Zika infection, were published in Nucleic Acid Research.

The Zika virus helicase is a motor enzyme that converts energy from nucleoside triphosphate to unwind and separate double - stranded nucleic acids, so the single - stranded genetic material can then be copied.

However, in the past decade scientists realized that exosomes play important roles in many biological functions through capsuling and delivering molecular messages in the form of nucleic acids and proteins from the donor cells to affect the functions of nearby or distant cells.

The FDA's new requirements would also extend to medically important «biologic» drugs — products composed of sugars, protein or nucleic acids that are typically made from living microorganisms.

Dr Ciro Chiappini, first author of the study from the Department of Materials, added: «If we can harness the power of nucleic acids and prompt them to carry out specific tasks, it will give us a way to regenerate lost function.

It asserted that bacterial death probably results from chlorine attacking a variety of bacterial molecules or targets, including enzymes, nucleic acids and membrane lipids.

It was not until the polymerase chain reaction technique for amplifying nucleic acids was developed in the late - 1980s that it became possible to do anything with the tiny and fragmentary biochemical evidence from insects embedded in amber.

While the bulk of CureVac's prize money will go to basic molecular immunology research, Hoerr says he also wants to set aside a portion to pay tribute to Miescher, the biologist from Switzerland who identified nucleic acids, a family of key biological molecules that includes DNA and RNA, in his lab in Tübingen.

And a new prototype device can display a fluorescent letter in the presence of nucleic acid sequences from the Ebola virus or the closely - related Marburg virus: «E» for Ebola or «M» for Marburg.

For these tests, doctors isolate and amplify viral nucleic acid in samples from an infected patient.

Attendees at the astrobiology meeting in Arizona showcased an assortment of high - tech devices for next - generation exploration, ranging from microfluidic «life analyzers» and integrated nucleic acid extractors for studying «Martian metagenomics» to exquisitely sensitive, miniaturized organic chemistry labs for spotting tantalizing carbon compounds and minerals at microscopic scales.

But what keeps these receptors from reacting to the host cells» own nucleic acids in the cytoplasm and causing unwanted inflammation?

«We had previously learned that messenger RNA, a nucleic acid present in all living cells whose primary role is to act as a messenger carrying instructions from DNA, moves between parasitic plants and their hosts, but we have yet to discover the significance of this exchange.

Ribonucleic acid or RNA is a nucleic acid polymer consisting of nucleotide monomers that plays several important roles in the processes that translate genetic information from deoxyribonucleic acid (DNA) into protein products;

Genetic therapies, such as those made from DNA or RNA, face challenges because of the difficulty in delivering the nucleic acid to the right cells.

Palazzo painstakingly picked out centrosomes from large and easily manipulated surf clam eggs and detected nucleic acids in the concentrated extract.

Life on Earth originated in an intimate partnership between the nucleic acids (genetic instructions for all organisms) and small proteins called peptides, according to two new papers from biochemists and biologists at the University of North Carolina at Chapel Hill and the University of Auckland.

Antisense inhibitors are synthetic nucleic acid drugs that can be designed to selectively bind to messenger RNA from the targeted, disease - linked gene, and inactivate it.

miRNA - 335, a messenger nucleic acid, regulates the endodermal transcription factors Sox17 and Foxa2 and is essential for the differentiation of cells within this germ layer and their demarcation from the adjacent mesoderm.

However the team from the Krebs Institute for Nucleic Acids at the University of Sheffield found that the key to preventing resistance to a common class of chemotherapy used to treat breast and colon cancer is to change the speed in which the cancer cells repair damage to their DNA that is introduced by chemotherapy.

Bacterial microbes face a never - ending onslaught from viruses and invasive snippets of nucleic acid known as plasmids.

Early life may have emerged from a mixture of RNA and DNA building blocks, developing the two nucleic acids simultaneously instead of evolving DNA from RNA.

The result was several series of nucleic acid duplexes that ranged from having all RNA nucleotides to none at all.

Being derived from a sugar containing only four carbons, TNA is structurally the simplest of all potentially natural oligonucleotide - type nucleic acid alternatives studied thus far.

Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild - living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35 %.

For each sample type, a standard curve for the TMAdV PCR assay was calculated from 3 PCR replicates at each dilution of nucleic acid extracted from the spiked matrix (data not shown).

Modern molecular technologies (genomics and other omics), through comparing nucleic acid and amino acid sequences across living species, are enabling the identification of genetic components and patterns stingily conserved by evolution, from those in which times of evolutionary branching of the tree of life can be inferred.

Szostak was pursuing the idea that life might have originated from the self - replicating nucleic acids that make up RNA.

TNGB collects, stores and distributes high quality biological materials (nucleic acids, cell lines and tissue samples) linked to relevant clinical and genetic data from patients affected by inherited diseases.

Toukach, P.V., Egorova, K.S. Carbohydrate structure database merged from bacterial, archaeal, plant and fungal parts (2016) Nucleic Acids Research, 44 (D1), pp.

The insights we expect to gain from this study of mitochondria dysfunction and microRNAs, and what they tell us about how some RPE cells become diseased while neighboring cells are either resistant or susceptible to disease, hold promise of becoming the basis for entirely new therapies for individuals suffering from AMD, built upon nucleic acid - based treatments aimed at rejuvenating RPE cell mitochondria.

For the positive control, nucleic acid extracted from virus stocks was used.

Therefore it is critical that nucleic acid - sensing TLRs bind their ligands and signal from the endocytic / phagocytic pathway.

Target information above from: UniProt accession P46013 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res.

Dean Madden and John Schollar from the National Centre for Biotechnology Education at the University of Reading, UK, suggest a recipe for a cocktail containing deoxyribose nucleic acid (DNA.)

We reasoned that contamination from XMRV - infected LNCaP cells was more likely given that the laboratory at the Cleveland Clinic performing the nucleic acid extractions in 2004 was simultaneously working with LNCaP and had only worked with 22Rv1 more than 2 years prior.

Target information above from: UniProt accession Q9UBK2 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res.

For high - throughput screening using fragment analysis, RNA was isolated using a MagnaPure LC system with a MagnaPure LC total nucleic acid isolation kit (Roche) according to instructions from the manufacturer.

Total RNA was isolated using the RNeasy Mini Kit from Qiagen and treated with RNase - free DNase I (5 units / 100 µg of nucleic acids, Sigma).

In addition to Orgel and Ghadiri, authors on the paper, entitled «Self - Assembling Sequence - Adaptive Peptide Nucleic Acids,» are Yasuvuki Ura, John Beierle, and Luke Leman, all from The Scripps Research Institute.