Growth hormones play an important role in this process, as it stimulates the transport of both amino and
nucleic acids into the cytoplasm of a cell.
We developed a way of getting siRNAs into epithelial cells by either mixing them with a transfection lipid used to introduce exogenous
nucleic acids into cells in the lab or by adding a cholesterol tag to the end of the RNA sequence that allowed the RNA to be taken up into cells.
By injecting short
nucleic acids into rats, researchers have blocked an enzyme linked to swelling and tissue damage in the lungs.
The spherical structure of the SNAs is the ideal architecture for delivering
nucleic acids into cells for gene regulation, Mirkin said.
Not exact matches
Nucleotides and amino
acids are substances which, there is reason to believe, could have been formed, and polymerized
into nucleic acid and protein respectively, under certain conditions on a lifeless earth.
The field segregates
into three major strategies: detecting free
nucleic acids, isolating intact circulating tumor cells, and identifying extracellular vesicles from tumors.
But before life arose, nitrogen fixation must have occurred via purely chemical means: That's because amino
acids and
nucleic acids, which both contain nitrogen, were likely the organic compounds that developed
into Earth's first lifeforms.
In a trial described in Nature Materials, the team showed they could deliver the
nucleic acids DNA and siRNA
into human cells in the lab, using the nanoneedles.
Most research
into life's origins has focused on how organic building blocks, like amino
acids and
nucleic acids, arose and assembled themselves
into proteins and RNA.
Ribonucleic
acid or RNA is a
nucleic acid polymer consisting of nucleotide monomers that plays several important roles in the processes that translate genetic information from deoxyribonucleic
acid (DNA)
into protein products;
But it's still a mystery how the amino
acid building blocks were first assembled according to coded
nucleic acid templates
into the proteins that formed the machinery of all cells.
The origin of life is not the same as the origin of its constituent building blocks, but laboratory studies on the linking of amino
acids into molecules resembling proteins and on the linking of nucleotides
into molecules resembling
nucleic acids are progressing well.
Investigations of how short chains of
nucleic acids replicate themselves in vitro have even provided clues to primitive genetic codes for translating
nucleic acid information
into protein information, systems that could have preceded the elaborate machinery of ribosomes and activating enzymes with which cells now manufacture protein.
Another idea is to probe the mother's bloodstream for cells and
nucleic acids shed by the placenta as a window
into the function of the organ.
The chemical stability of these two
nucleic acids should also be considered when thinking about how they could become incorporated
into the earliest forms of life, he adds.
Like infinitesimally small Lego blocks, the
nucleic acids that make up RNA connect to each other in very specific ways, which force RNA molecules to twist and loop
into a variety of complicated 3D structures.
Exosomes are tiny packets of proteins, microRNA and
nucleic acids that cells emit
into their environment to both communicate with neighboring cells and influence their behavior.
He has been actively involved in the discovery of several
nucleic acid and peptide drug leads that were progressed
into clinical studies.
It also delves
into the history and science of the story of DNA, a
nucleic acid which contains the genetic instructions that form the basis for all living organisms.
We are excited to announce that our successful work of backing up two mitochondrial genes
into the nuclear genome has been accepted for publication in the journal
Nucleic Acids Research!
Dr. Maria DeRosa's research examines a type of
nucleic acid called «aptamers» that can fold
into 3D nanoscale shapes capable of binding tightly to a specific molecular target.
Such enzymes will break down sugars,
nucleic acids, amino
acids, and fatty
acids so that they are more easily assimilated
into the body.
The blueprint for life is a chain of
nucleic acids formed
into DNA molecules.
After invading the cells, papilloma viruses insert their genetic information
into the host cell's DNA (
nucleic acid) and upset the normal regulatory mechanisms of cell division, so that the cell divides abnormally and more frequently.
Has represented
nucleic acid therapeutics company from start - up through IPO and
into clinical trails, crafting an IP portfolio with layered protection of both platform technologies and key product candidates, including in support of major collaborations.