Sentences with word «nucleocytoplasmic»
«Important role of nucleocytoplasmic transport in amyotrophic lateral sclerosis and frontotemporal dementia.»
sciencedaily.com
Prof. Ludo Van Den Bosch (VIB / KU Leuven): «This is the first time that we see a role for nucleocytoplasmic transport for these specific forms of ALS and FTD.
These screens were strongly enriched for genes controlling nucleocytoplasmic transport.
As a consequence, modulating nucleocytoplasmic transport could become a promising and new therapeutic avenue.»
Prof. Wim Robberecht (VIB / KU Leuven): «Recently, two other papers were published in Nature using fruit flies containing C9orf72 repeats, yielding both toxic repeat RNA and toxic DPRs and these also concluded that defective nucleocytoplasmic transport is important in C9orf72 ALS and / or FTD.
«Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting.»
Molecular mechanisms and functions of SUMOylation; nuclear pore complexes and control of nucleocytoplasmic transport.
These components are the mitochondria (derived from purple bacteria), the plastids (from cyanobacteria), and the nucleocytoplasmic component (from archaebacteria).
«The nucleocytoplasmic component of the eukaryotic cell branches off very early in the evolutionary radiation of the archaebacteria.
A team of scientists from VIB and KU Leuven now discovered that proteins translated from this tandem repeat interfere with the nucleocytoplasmic transport which they found is essential for causing ALS and FTD.
Bioinformatic analyses suggest that glycine - arginine and proline - arginine repeats could mimic the nuclear localization signals of these proteins and hence hijack nuclear import by overloading the nucleocytoplasmic transport system.