The investigators uncovered a number of host factors that were deactivated by early viral proteins and identified a subgroup
of nucleolar proteins that aid virus replication.
The related BAZ2A (also called TIP5) protein plays a central role in the NoRC (
nucleolar remodeling complex).
The paper is important, says developmental biologist Jirí Kanka at the Institute for Animal Physiology and Genetics in Libêchov, Czech Republic, because it shows the contribution of a single protein to the complex process of
nucleolar disassembly.
The syndrome is associated with mutations in the TCOF1 gene which encodes a
putative nucleolar phosphoprotein known as treacle.
Alterations in CDK1 expression and nuclear /
nucleolar localization following induction in a spontaneous canine mammary cancer model.
Aging in yeast is accompanied by
nucleolar enlargement and fragmentation, suggesting a mechanism of cellular aging that may be related to nucleolar structure.