Sentences with word «nucleoprotein»

The combination of high crosslinking yields, excellent specificity, and elimination of photodamage to other chromophores represents an important advance toward the precise identification of contacts in nucleoprotein complexes.

Immunohistochemical analysis for H5N1 virus nucleoprotein detection in merit release birds» organs (experimentally infected).

Working in the lab of biochemist and Nobel laureate Edward Tatum, Finch attempted to isolate nucleoproteins from the bread mold Neurospora.

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

Telomeres are nucleoprotein complexes located at the ends of chromosomes, essential for chromosome protection and genomic stability.

The mouse is described in a study, «In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein,» that will be published April 10 in The Journal of Experimental Medicine.

Immunohistochemical staining of the tissues was carried out for the influenza nucleoprotein detection in sparrows» tissues.

A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

Adrenal glandular substance, made from animal adrenal glands, is also recommended to provide adrenal nucleoprotein and other factors to help rebuild the adrenal glands.

Now, a team at the University of Virginia (UVA), USA — under the leadership of Dr Dan Engel, a virologist, and Dr Zygmunt Derewenda, a structural biologist — has obtained the crystal structure of a key protein involved in Ebola virus replication, the C - terminal domain of the Zaire Ebola virus nucleoprotein (NP).

«This genomic RNA has not been targeted because the dogma was that it is completely encapsulated by the viral nucleoprotein, and therefore is not accessible.»

Their search turned up a suspect: a piece of a receptor for hypocretin resembles part of the H1N1 influenza nucleoprotein — which binds to the virus genome and plays a key role in its replication.

Like many other related viruses, Ebola virus contains a negative - sense, single - stranded RNA that encodes seven different proteins, one of which is known as the nucleoprotein (NP) for its ability to interact with the viral RNA genome.

AVI - 7288 specifically targets the viral messenger RNA that encodes Marburg virus nucleoprotein.

In December, Outi Vaarala of the University of Helsinki and her colleagues had reported that Pandemrix contained a much higher level of nucleoprotein than a GSK vaccine called Arepanrix, which was associated with a much smaller risk for narcolepsy.

The researchers also showed that Focetria, which has not been linked to narcolepsy, had a much lower concentration of nucleoprotein than Pandemrix did.

The flu vaccine is designed to trigger antibodies to influenza's surface proteins, but if it elicits antibodies to the nucleoprotein as well, those might well latch on to the hypocretin receptor, and eventually lead to death of the cells, the researchers thought.

The group also found that children with narcolepsy had an altered immune response to the nucleoprotein in Pandemrix.

The study also suggests ways to make influenza vaccines even safer, for instance by keeping the nucleoprotein levels low or removing the specific region of the protein that mimics the receptor.

Some of the same researchers already had circumstantial evidence that the nucleoprotein might be an important player.

MxA is thought to target influenza A by binding to the nucleoprotein that encapsulates the virus» genome, and mutations in this nucleoprotein have been linked to the virus» ability to infect human cells.

MxA is therefore a barrier against cross-species influenza A infection, but one that the virus can evade through a few mutations in its nucleoprotein.

A group led by Chi - Huey Wong at National Taiwan University is continuing the work, finding nucleozin analogs and also finding more precise targets within the nucleoprotein.

She then compared the amino acid sequences of the nucleoprotein from different influenza viruses, finding that the oligomerization loop is a well - conserved feature.

Her first major discovery, in 2006, identified a loop in the nucleoprotein of the H1N1 human influenza virus.

Every negative - sense RNA virus encodes a nucleoprotein that surrounds the virus genome and allows it to replicate.

The high - resolution structure of a filamentous flexible plant virus shows that there is structural homology between its coat protein and the nucleoproteins of an unrelated group of enveloped RNA animal viruses.

Crystal structure of the Lassa virus nucleoprotein - RNA complex reveals a gating mechanism for RNA binding.