The Cac2 subunit is essential for productive histone binding and
nucleosome assembly in CAF - 1.
We have developed a quantitative
nucleosome assembly (NAQ) assay that measures nucleosome formation in vitro (Figure 2).
CAF - 1 orchestrates histone deposition and
nucleosome assembly during DNA replication.
In a second study, published in 2016 in the EMBO Journal, the Panne group reported on the second
nucleosome assembly step.
In a biochemical study in 2017 in eLife, Panne's group reported on the first step of
nucleosome assembly.
«Our paper shows that suppressing ASF1 induces ALT by affecting
nucleosome assembly,» he says.
Not exact matches
Gene ontology analysis of the genes affected across several tissues (Supplementary Fig. 8) shows enrichment for genes in the extracellular region and genes involved in
nucleosome and chromatin
assembly and in protein — DNA complexes.