Sentences with phrase «nucleosome shape»
In a study published in Molecular Cell this month, Alexei V. Tulin, PhD, Associate Professor at Fox Chase Cancer Center, and colleagues reported that chemical modification of one type of histone — called H2Av — leads to substantial changes in nucleosome shape.
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Made up of nucleosomes — roll - shaped bundles of DNA and protein — the heterochromatin is connected by a velcro - like feature called «Heterochromatin Protein 1 (HP1).»
They found that the addition of a phosphate group to a histone — called H2Av — triggered the entire nucleosome to change shape, exposing previously hidden parts of the nucleosome that began to interact with and activate PARP1.