Sentences with phrase «nucleosomes at»

We believe that the presence of dynamic nucleosomes at highly expressed genes helps to unwind this spring rapidly and as often as necessary,» comments David Shore.

The team observed a relative scarcity of nucleosomes at telomeres from ASF1 - depleted cells, as one might expect once a histone chaperone is lost.

Not exact matches

In January, a team at the University of Washington, Seattle, described in Cell a test that relies on tissue - specific differences in how DNA is packaged in structures called nucleosomes.

In a study published in Molecular Cell this month, Alexei V. Tulin, PhD, Associate Professor at Fox Chase Cancer Center, and colleagues reported that chemical modification of one type of histone — called H2Av — leads to substantial changes in nucleosome shape.

Although it has not been established that CenH3 alone determines centromere identity, the sequence of a complete centromere should at the least include the entire region that is wound around nucleosomes containing CenH3.

«It is important to understand how nucleosomes are moved, ejected or restructured, as this will affect the accessibility of promoter DNA, which in turn influences the expression of the corresponding genes,» explains David Shore, professor at the Department of Molecular Biology of the Faculty of Science at UNIGE.

In collaboration with researchers at the Department of Computer Science (UNIGE) and the Swiss Institute of Bioinformatics at EPFL, David Shore's team has undertaken to characterize nucleosomes present in every gene promoter of yeast DNA.

One type, characterized by the presence of dynamic, unstable, nucleosomes, is found at highly expressed genes, such as those involved in the control of cell growth and division.

The other type, which contains well - known stable nucleosomes, is located at less frequently expressed genes.

«We have revealed the existence of two types of promoters, which differ by the presence of «fragile» nucleosomes,» says Slawomir Kubik, first author of the study and researcher at UNIGE.

In 2012, for example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev says.

In an interdisciplinary team effort, we study the conformation of the genome at various scales, from the nucleosome fiber to the distribution of chromosomes territories in the nuclear space.

DAXX recruitment to enhancers was at the nucleosome - free region, alongside other transcription factors and co-factors (Figure 1D).

(A) and (B) show the distribution of nucleosome formation potential scores at 400 and 2000 bp upstream from the gene start site respectively.

Looking more closely at the passage above and comparing it to the content of the National Science Education Standards (NSES)(National Research Council, 1996) shows that a single paragraph from the most commonly used high school biology textbook in the United States includes at least six scientific terms (eukaryotic, chromosome, prokaryote, chromatin, histone, and nucleosome) that are, unlike DNA and protein, not included in the NSES.