The DNase I data exploits a structural feature of regulatory DNA that's been known for decades: the binding of sequence - specific transcriptional regulators in place of
nucleosomes creates DNase I hypersensitive sites, or DHSs.
Not exact matches
When a given gene needs to be transcribed to
create new proteins, its promoter region must be unwrapped from the
nucleosome so that it can be accessed by the factors involved in initiating the transcription process.
The four histones
create a new
nucleosome spool for that section of DNA.