Sentences with phrase «nucleotide analogue»

Finally, other enzymes in the liver easily dislodged the phosphate group from the nucleotide analogue, rendering the compound ineffective.

Results from three Phase III clinical trials (ION - 1, ION - 2 and ION - 3) evaluating the investigational once - daily fixed - dose combination of the nucleotide analogue polymerase inhibitor sofosbuvir (SOF) 400 mg and the NS5A inhibitor ledipasvir (LDV) 90 mg, with and without ribavirin (RBV), for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection have been presented at the International Liver CongressTM 2014.

A company called Pharmasset had been looking at a group of drugs known as nucleotide analogues, which met some of these criteria, since the mid-2000s.

Because the nucleotide analogues were water - soluble, they could not traverse the fatty lining of the intestine (fats and water do not mix) to reach the bloodstream and then the liver.