Sentences with phrase «nucleotide binding»

In both PKA and PKG, the R domains seem to contact each other through their cyclic nucleotide binding domains.

β - Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein — coupled receptor (GPCR) desensitization, also function in internalization and signaling of these receptors.

A single - stranded, 3» extension of three nucleotides bound to the 3» to 5» exonuclease active site.

When two nucleotides bind to a pair of units, the pair is then able to connect with another pair to form the four - part active enzyme.

● Chemically, ATP is an adenine nucleotide bound to three phosphates.

Not exact matches

Microspheres are then able to use proteinoids as templates to make polynucleotides, which are themselves nonrandom because specific three - nucleotide sequences bind preferentially to specific amino acids.

In aqueous solution, 1 binds readily to a variety of biomolecules, including nucleotides, RNA, amino acids, peptides, and phospholipids.

Heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)- bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors.

The β2 - adrenergic receptor (β2AR) is a well - studied prototype for heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters.

By binding to a stem structure formed by uracil and adenine nucleotides in the nanos RNA, Glo prevents the production of Nanos protein at the front of the embryo, a step that enables the fly's head to form properly.

Such probes, about 20 nucleotides long, sometimes bind loosely to sequences slightly different from the target sequence.

Smith's group substituted one of the probe's bases with 3 - nitropyrrole, a molecule that is shaped like a nucleotide but that doesn't bind to one on an opposite strand.

RIPK2 works in conjunction with NOD1 and NOD2 (nucleotide - binding oligomerization domain) proteins in controlling responses by the immune system that lead to this inflammation process.

Hormones and neurotransmitters may mediate common responses through receptors that couple to the same class of heterotrimeric guanine nucleotide — binding (G) protein.

While most enzymes remain active only as long as their activators are bound, Stivers» group found that SAMHD1 remains active for about half a day after its activators have fallen off, enabling the enzyme to get cellular nucleotides to really low levels that make it almost impossible for HIV to infect cells.

Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.

The sugars are bound together by the phosphate groups, forming the backbone of the DNA, and each sugar has a nucleotide base attached to it.

MinE activates the enzymatic activity of membrane - bound MinD, thus triggering the conversion of its bound nucleotide adenosine triphosphate (ATP) to adenosine diphosphate (ADP), which causes the release of MinD - ADP into the cell cytoplasm.

When a methyl group (a carbon atom with three hydrogen atoms attached) binds to a cytosine molecule (one of the four nucleotides that make up DNA), it tells the cell's transcription machinery not to transcribe that gene.

This binding site is occupied in case of nucleotide misincorporation in the RNA or damage to the DNA, and is termed the «P» site because it supports proofreading.

Cloning and sequencing of complementary DNA's from normal and WHHL rabbits, shows that this defect arises from an in - frame deletion of 12 nucleotides that eliminates four amino acids from the cysteine - rich ligand binding domain of the LDL receptor.

MicroRNAs (miRNA) are a class of noncoding RNAs with lengths of approximately 22 nucleotides that bind to target messenger RNAs to inhibit protein translation.

Called individual nucleotide resolution crosslinking immunoprecipitation (iCLIP), the technique enabled Sanford's lab to identify IGF2BP3 binding sites in several hundred RNA transcripts in two B - ALL cell lines.

Traditional methods for mapping HIV genetic material use long strings of these nucleotides, called oligomers, to find and bind to complementary strands of DNA or RNA in sample tissues.

Two specific long - range interactions clamp the two halves of the domain together: a two - Mg2 + - coordinated adenosine - rich corkscrew plugs into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11 - nucleotide internal loop.

Where Cas9 finds N - G - G immediately following the 20 nucleotides, it attaches to and opens the double helix, allowing the gRNA to bind.

These mutations all occur after nucleotide 7000 in the C - terminus of BRCA2, which includes the DNA binding domains, tower domains, and OB folds.33 These functional domains are associated with localization of BRCA2 to sites of double - stranded DNA breaks to accomplish repair.33 These data suggest that intact protein may be protective when it comes to ovarian cancer risk.

The nucleotide - binding oligomerization domain - containing protein 1 (NOD1) polymorphism S7N does not affect receptor function.

Using a proprietary protocol DNA fragments are bound directly onto the surface of the magnetic beads, leaving unincorporated nucleotides, primers, primer dimers, and other contaminants in solution.

Effects of Arp2 and Arp3 nucleotide - binding pocket mutations on Arp2 / 3 complex function.

Nucleotides and phosphorylation bi-directionally modulate CaMKII binding to the NMDA - receptor subunit GluN2B.

Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin - dependent protein kinase II (CaMKII) binding to the N - methyl - D - aspartate (NMDA) receptor subunit GluN2B.

The functionally active ABC proteins consist of four domains, two transmembrane domains (TMDs) and two nucleotide - binding domains (NBDs).

piRNAs are small RNA molecules (26 - 31 nucleotides in length) that bind to a class of germline - specific proteins called PIWIs.

Retinoic Acid - induced Gene - I (RIG - I) Associates with Nucleotide - binding Oligomerization Domain - 2 (NOD2) to Negatively Regulate Inflammatory Signaling.

CNGs open after direct binding of cyclic nucleotides, cAMP, and cGMP.

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

About 95 % of the time, Ago bound within 45 - 62 nucleotides of this peak, so the authors defined this region as the average Ago - miRNA footprint.

Using the new solution, DNA fragments are bound directly onto the surface of the magnetic beads, leaving unincorporated nucleotides, primers, primer dimers, and other contaminants in solution.

The AMPK sample contains an kinase activating compound and three AMP nucleotides (ATP - depleted scenario) bound to it.

In a proof of principle study, we found that a previously undescribed single nucleotide polymorphism in the binding domain of the erythrocyte binding like protein (EBL) conferred a dramatic change in red blood cell invasion in mutant rodent malaria parasites Plasmodium yoelii.

The XPA - binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways

For a chemical perspective adenosine triphosphate is an adenine nucleotide, which binds itself to 3 different groups of phosphatee types.