All reads covering a given position yielded the same (corrected) nucleotide, indicating that previous
nucleotide differences in published genomes [1](red lollipops) are due to sequencing error.
Humans and chimps each have somewhere between 20,000 and 30,000 genes, so there are likely to be
nucleotide differences in every single gene.
Not exact matches
«The mean
difference in leukocyte telomere length between the most active and least active subjects was 200
nucleotides (chemical structural units of DNA and RNA), which means that the most active subjects had telomeres the same length as sedentary individuals up to 10 years younger, on average.»
Single -
nucleotide polymorphisms (SNPs — pronounced «snips») are the most common type of human genetic variation; each one represents a small
difference in a
nucleotide — the building blocks of our DNA.
Samani and his colleagues analyzed more than 500,000 genetic variations (naturally occurring, single -
nucleotide differences) spanning the genome
in blood cells collected from almost 3,000 people.
One might assume that the
differences between chimp and human genes boil down to those sorts of typographical errors: one
nucleotide being swapped for a different one and altering the gene it sits
in.
When the chimp and human genomes are compared, some of the clearest cases of
nucleotide differences are found
in genes coding for transcription factors.
HapMap is a directory of «single
nucleotide polymorphisms,» or SNPs, places
in the genome where
differences between individuals (
in the form of single chemical letters) appear
in the DNA code.
In genomes involving billions of
nucleotides, a tiny 2 percent
difference translates into tens of millions of ACGT
differences.
Then they checked blood samples against half a million known variations
in DNA sequences, or single -
nucleotide polymorphisms, which recently were identified by the International HapMap Project that looked for
differences in the genomes of people from many populations.
Penn Vet researchers showed that
differences in the order of
nucleotides — not the amino acids — governed the distinct functions of two forms of actin.
Looking for single
nucleotide polymorphisms (SNPs) or subtle variations
in the DNA sequence, they found
differences in AHR2, which plays an important role
in mediating toxicity
in early life stages.
The tests look for
differences in the DNA
nucleotides adenosine, thymine, guanine, and cytosine (A, T, G, and C — the letters of the genetic code) between one person and another, or between one group of people and another group.
Scott D. Collins, Ph.D., University of Maine, Orono $ 850,000 (2 years) «High - speed Nanopore Gene Sequencing» Skilled
in silicon fabrication methods, this group will try to fabricate a nanopore with tiny electrodes and built -
in circuits that will be used
in experiments that attempt to measure
differences in the electron tunneling of individual
nucleotides in DNA molecules.
It will then test the device to see if it is possible to distinguish between the four types of
nucleotides based on
differences in a phenomenon called electron tunneling.
They do this by aiming for little genetic
differences in DNA called single
nucleotide polymorphisms, or «SNPs» (pronounced «snips»).
The
difference in nucleotides between the two ends was calculated; a negative value indicates the 5 ′ end reported by Clowney et al. is upstream of the one reported here, by Cufflinks [33].
The
difference in nucleotides between the two ends was calculated; a negative value indicates the 5 ′ end reported by nanoCAGE is upstream of the one reported by Cufflinks.
By SNP analysis, single
nucleotide differences between the sequences of 22Rv1 - associated XMRV and XMRV genomes detected
in prostate cancer tissues [VP35, VP42, and VP62 (2006)-RSB-(red lollipops) are corrected by the deep sequencing coverage data (black lollipops).