Sentences with phrase «nucleotide exchange factor»

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.
Mechanistic investigations revealed that RASSF1A blocked tumor growth by stimulating cofilin / PP2A - mediated dephosphorylation of the guanine nucleotide exchange factor GEF - H1, thereby stimulating its ability to activate the antimetastatic small GTPase RhoB.
In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesis.
The guanine nucleotide exchange factor (GEF) for Rho, p115 RhoGEF, has an amino - terminal region with similarity to RGS proteins.
Depletion of dynamin - binding protein or Tuba, a guanine nucleotide exchange factor, disrupted renal ciliogenesis in cell culture and led to abnormal kidney morphology in a Tuba knockdown zebrafish model of PKD.
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