Sentences with phrase «nucleotide excision»
Nucleotide excision refers to a process in which a damaged or incorrect piece of DNA (called a nucleotide) is removed and replaced with the correct one. It's like fixing a mistake in the DNA code to ensure that it functions properly. Full definition
A multinational research team led by Richard Wood of the Imperial Cancer Research Fund's Clare Hall laboratories in Hertfordshire has recreated this vital mechanism, called nucleotide excision repair (NER), in the test tube.
newscientist.com
ERCC1 - XPF is an endonuclease complex required for nucleotide excision repair, interstrand crosslink repair and the repair of a subset of DNA double - strand breaks.
Now scientists from the UNC School of Medicine have confirmed and clarified key molecular details of one of these repair systems, known as nucleotide excision repair.
If RNA polymerase encounters a lesion in DNA, the theory went, backtracking could make room for repair enzymes to fly in, cut out the damaged section, and rebuild a normal chain in a process called nucleotide excision DNA repair (NER).
Guo R, Chen J, Zhu F, Biswas AK, Berton TR, Mitchell DL, Johnson DG (2010) E2F1 localizes to sites of UV - induced DNA damage to enhance nucleotide excision repair.
Guo R, Chen J, Mitchell DL, Johnson DG (2011) GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.
Wood is widely known for his pioneering work in nucleotide excision repair and is a Fellow of The Royal Society.
It revealed that the «nucleotide excision repair» system works much more efficiently in the active genes of plants as compared to humans.
XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].
Mitchell D, Paniker L, Godar D (2012) Nucleotide excision repair is reduced in oral epithelial tissues compared with skin.
Tsodikov studied a human DNA repair pathway, nucleotide excision repair, focusing on enzymes that cleave damaged DNA.