A multinational research team led by Richard Wood of the Imperial Cancer Research Fund's Clare Hall laboratories in Hertfordshire has recreated this vital mechanism,
called nucleotide excision repair (NER), in the test tube.
Now scientists from the UNC School of Medicine have confirmed and clarified key molecular details of one of these repair systems, known
as nucleotide excision repair.
ERCC1 - XPF is an endonuclease complex required
for nucleotide excision repair, interstrand crosslink repair and the repair of a subset of DNA double - strand breaks.
It revealed that the «
nucleotide excision repair» system works much more efficiently in the active genes of plants as compared to humans.
XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via
the nucleotide excision repair (NER) pathway [6,7].
Mitchell D, Paniker L, Godar D (2012)
Nucleotide excision repair is reduced in oral epithelial tissues compared with skin.
Tsodikov studied a human DNA repair pathway,
nucleotide excision repair, focusing on enzymes that cleave damaged DNA.