Sentences with phrase «nucleotide level»
The phrase "nucleotide level" refers to the smallest building blocks of DNA or RNA molecules. These are tiny structures that combine to form genes and carry important information for cell functions. Full definition
The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer.
sciencedaily.com
Thus, when nucleotide levels are low and c - MYC concentration drops, transcription will be down - regulated as well.
Resolving nucleotide modifications at the single molecule, single nucleotide level, especially when integrated with other single molecule - or single cell - level data, such as RNA and protein expression, will help resolve regulatory relationships that govern higher order phenotypes such as drug resistance» said Eric Schadt, Ph.D., founding director of the Icahn Institute and professor of genomics at the Icahn School of Medicine at Mount Sinai.
«That's how SAMHD1 can get the nucleotide levels so low that viruses are thwarted.»
FRT sites and loxP sites differ at the nucleotide level but share an overall structure of 13 base pair palindromic repeats separated by an 8 bp asymmetric core.
Identification of significant phylogenetically informative sites at the nucleotide level revealed positions not only contributing to clade differentiation, but which are located at or proximal to codons associated with resistance to protease inhibitors (NS3 Q41) or polymerase inhibitors (NS5B S368).
Characterization of balanced chromosomal rearrangements at the nucleotide level has led to translation of the methods into the clinic in the setting of prenatal diagnosis and to the development of a suggested next - gen cytogenetic nomenclature.
First, we identified a mutation at the nucleotide level utilizing QTL analysis and provided genetic, biochemical and physiological evidence that CYFIP2 is a regulator of acute and sensitized cocaine response.