Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a
discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single -
nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.
The
discovery of single -
nucleotide polymorphisms — and inferences about human demographic history Wakeley, J., R. Nielsen, S. Neen Liu - Cordero, and K. Ardlie.