Sentences with phrase «nucleotide polymorphism in»

For those of you not on Team Cilantro, consider this your talking points... and impress your naysaying cilantro - loving friends by boasting about your unique version of a single - nucleotide polymorphism in the area of chromosome 11!

In a proof of principle study, we found that a previously undescribed single nucleotide polymorphism in the binding domain of the erythrocyte binding like protein (EBL) conferred a dramatic change in red blood cell invasion in mutant rodent malaria parasites Plasmodium yoelii.

Genome - wide patterns of nucleotide polymorphism in domesticated rice.

Genome - wide patterns of nucleotide polymorphism in domesticated rice Caicedo, A. L., S. H. Williamson, R. D. Hernandez, A. Boyko et al. 2007.

Large - scale resequencing of the first ESTs and subsequent genotyping of single nucleotide polymorphisms in large populations expanded the available molecular marker resources and provided a basis for examining their association with traits of interest (Eckert et al. 2013).

We will then validate the generalizability of protective human immune responses against Clone 10 and other candidate antigens in an independent cohort of Tanzanian children, and investigate potential single nucleotide polymorphisms in Clone 10 from P. falciparumfield isolates from Tanzania.

Single nucleotide polymorphisms in genes for 2» -5» - oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.J Infect Dis.

Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single - nucleotide polymorphisms in / near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single - nucleotide polymorphisms in / near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass.

A simple correction for multiple testing for single - nucleotide polymorphisms in linkage disequilibrium with each other

Not exact matches

In genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphismsIn genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphismsin genomes, so - called SNPs (single nucleotide polymorphisms).

Their preliminary analysis revealed several mutations known as single nucleotide polymorphisms (SNPs) in the ALR gene, many of which haven't been identified before.

Single - nucleotide polymorphisms (SNPs — pronounced «snips») are the most common type of human genetic variation; each one represents a small difference in a nucleotide — the building blocks of our DNA.

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

The research team's hunt for such age - related genetic associations involved studying more than 8 million single nucleotide polymorphisms — changes of one nucleotide for another at a particular spot in the DNA — in 2,693 individuals.

The lab has also shifted from testing genetic markers known as short tandem repeats (STRs), which are standard in paternity testing, to recording single letter variants in the genetic code known as single nucleotide polymorphisms, or SNPs, which are rarely used for this purpose.

The research looked at more than five million genetic variations, called single nucleotide polymorphisms or SNPs (pronounced «snips»), in each participant in the study and compared the frequency of these SNPs with that of the control subjects.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

But ScienceInsider guesses that he was referring to a single nucleotide polymorphism (SNP) called rs762551 that modulates a caffeine metabolizing enzyme in the liver.

From beetles collected at 27 sites in Alberta and British Columbia, they looked for any patterns amongst their catalog of 1536 mutations (single - nucleotide polymorphisms, or SNPs).

The twins in the current study had already had their genomes analyzed, and 1.3 million small genetic variations (also known as single - nucleotide polymorphisms or SNPs) were known for each participant.

Single nucleotide polymorphisms (SNPs, used as genetic markers in DNA profiling) can produce single amino acid polymorphisms (SAPs) in the amino acids that make up protein.

To get a clearer picture of the settlement patterns, David Reich of Harvard Medical School in Boston and his colleagues compared DNA from 52 Native American populations across Canada, Greenland and Central and Southern America, focusing on variations called single - nucleotide polymorphisms (SNPs) in protein - coding and non-coding regions across the genome.

To resolve this paradox, we analyzed introns and demonstrated that these are deficient in single - nucleotide polymorphisms, as are synonymous sites in coding regions.

The DNA methylation revealed a much stronger link to survival than all other previously studied alterations in individual DNA building blocks (SNPs, single nucleotide polymorphisms).

HapMap is a directory of «single nucleotide polymorphisms,» or SNPs, places in the genome where differences between individuals (in the form of single chemical letters) appear in the DNA code.

To identify new genetic variations associated with different SLE phenotypes, a total of 598,258 different regions on the genome (known as single - nucleotide polymorphisms) were genotyped in a population of 482 Caucasian European SLE patients of Spanish origin recruited from the rheumatology departments of 15 Spanish university hospitals belonging to the IMID Consortium (SLE group).

Called the stairway plot, it models the frequency of single nucleotide polymorphisms (SNPs) in whole genome sequences of hundreds of individuals.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

To study natural selection, the team combed the International Haplotype Map for long stretches of DNA flanked by a single nucleotide polymorphism (SNP, or «snip»)-- that is, an altered base, or «letter,» in the genetic alphabet.

Each of the genetic variants studied by the researchers is a single - nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or nucleotide in some individuals, and where one «letter» is more commonly found in individuals with higher fracture risk.

They also identified SNPs (single nucleotide polymorphisms, or alterations to the genetic code created by the addition or deletion of a single nucleotide in a gene's long chain).

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

These variants, called single - nucleotide polymorphisms (SNPs, pronounced «snips»), are the route through which variations in traits such as hair and eye color, as well as many diseases, are often passed to future generations.

But the exact causes of the vast majority of autism - related disorders remain a mystery: classic genetic studies, which tie the ailment to single nucleotide polymorphisms (SNPs — deletions, additions or substitutions of one unit in the genetic code), have returned a number of different markers with very few well - replicated candidates.

Hill showed a single - nucleotide polymorphism — placed in the genome where a single nucleotide is altered — in this gene is «strongly associated» with elite sprint racing performance.

They pick out single bases that don't match the equivalent bases in another species — so - called single nucleotide polymorphisms.

Using these data, we built a genetic model that includes 150 single - nucleotide polymorphisms (SNPs) and found that it could predict EL with 77 % accuracy in an independent set of centenarians and controls.

Synonymous single - nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur.

In their study (1), Sebastiani et al. used a number of different genotyping platforms and neglected to perform data quality - control steps, which resulted in their reporting several false - positive single - nucleotide polymorphism (SNP) associationIn their study (1), Sebastiani et al. used a number of different genotyping platforms and neglected to perform data quality - control steps, which resulted in their reporting several false - positive single - nucleotide polymorphism (SNP) associationin their reporting several false - positive single - nucleotide polymorphism (SNP) associations.

It will build on the recently completed HapMap, which describes how blocks of DNA tagged by common variants, called single - nucleotide polymorphisms (SNPs), vary in different populations (ScienceNOW, 26 October 2005).

Then they checked blood samples against half a million known variations in DNA sequences, or single - nucleotide polymorphisms, which recently were identified by the International HapMap Project that looked for differences in the genomes of people from many populations.

They measured metabolites in a few thousand patients with MS, then matched the concentrations of metabolites with single nucleotide polymorphisms (SNPs).

The short note, by Editor - in - Chief Bruce Alberts, acknowledged that the study's authors «used a number of different genotyping platforms and neglected to perform data - quality control steps, which resulted in their reporting several false - positive single - nucleotide polymorphism (SNP) associations.»

The team identified 15 new genetic CAD associations, via SNPs — or single - nucleotide polymorphisms, places in genes in which the DNA building blocks differ from person to person by only one block, or nucleotide.

Looking for single nucleotide polymorphisms (SNPs) or subtle variations in the DNA sequence, they found differences in AHR2, which plays an important role in mediating toxicity in early life stages.

Objective To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and / or NSAIDs and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

The unit provides genetic testing services using a combination of both microsatellite and single nucleotide polymorphism (SNP) panels for characterizing and selecting breeders in a wide variety of inbred mouse strains subsequently used for the generation of congenic animals.