Sentences with phrase «nucleotide polymorphisms»
Nucleotide polymorphisms refer to small variations in the DNA sequence of an organism. It is like differences in the alphabet letters of a word. These genetic differences can affect how traits are inherited and can contribute to the uniqueness among individuals of the same species. Full definition
Large - scale resequencing of the first ESTs and subsequent genotyping of single nucleotide polymorphisms in large populations expanded the available molecular marker resources and provided a basis for examining their association with traits of interest (Eckert et al. 2013).
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Moreover, the rapidly growing catalog of single nucleotide polymorphisms in the human population, the decreasing cost of genotyping and whole - genome sequencing, the completion of the reference human DNA sequence and a haplotype map of the entire human genome provide unprecedented opportunities for advancing the study of complex genetic diseases.
Estimating population divergence time and phylogeny from single ‐ nucleotide polymorphisms data with outgroup ascertainment bias.
Correcting estimators of θ and Tajima's D for ascertainment biases caused by the single - nucleotide polymorphism discovery process Ramírez - Soriano, A. and R. Nielsen.
The researchers looked at functional single nucleotide polymorphisms within the CLOCK gene that are able to influence how much protein is transcribed from the gene.
«About one - third (or 1 million) of your SNPs [single nucleotide polymorphism] are dedicated solely to the job of determining how effectively your enzymes are controlled by the nutrients you consume.»
Linkage disequilibrium and inference of ancestral recombination in 538 single - nucleotide polymorphism clusters across the human genome.
Estimation of population parameters and recombination rates from single nucleotide polymorphisms Nielsen, R. 2000.
Rounding out the session were presentations from GenoMEL scientists from the United States, the Netherlands, Mexico, Scotland and Austria, including an update on the most recent GenoMEL genomewide association study of genetic variants called single nucleotide polymorphisms associated with increased risk of developing melanoma in the general population.
In the Diabetes Prevention Program, SHBG and SHBG - single nucleotide polymorphisms did not predict incident diabetes in any sex, but diabetes incidence was directly associated with estradiol and estron and inversely with testosterone in men (62).
Lectin may cause leptin resistance, affecting its functions (signal have high levels of leptin and several effects gathering to protect from lipid overload), as indicated by studies on effects of single nucleotide polymorphisms on the function of leptin and the leptin receptor.
Eight Single Nucleotide Polymorphisms Used as an Instrument for Increased Waist - To - Hip Ratio Adjusted for Body Mass Index in Women but not in Men
They investigated genetic divergence among the alders based on 1,077 single nucleotide polymorphisms obtained from the alders» genome, finding variations in their DNA sequencing.
The study, «Analysis of DNA from post-blast pipe bomb fragments for identification and determination of ancestry,» examined different collection and extraction methods for degraded and small samples of DNA left behind on detonated pipe bombs, including short tandem repeat markers (SNPs), single nucleotides polymorphisms via a new sequencing method called massively parallel sequencing or MPS, and insertion / null (INNULs).
In the human family tree, says Tyler - Smith, «the single - nucleotide polymorphisms give you the trunk and the main branches.
The study also tested whether 3 single - nucleotide polymorphism multilocus genotype responsiveness patterns or insulin secretion (INS - 30; blood concentration of insulin 30 minutes after a glucose challenge) were associated with weight loss.
Keeping in mind that the ~ 1,200 alleles known to exist for the CTRF gene implicated in the common autosomal recessive disorder cystic fibrosis alone [29] can theoretically result in ~ 700,000 different allelic combinations, the potential number of allelic combinations of different recessive mutations and single nucleotide polymorphisms genome - wide is currently incalculable.
While the HapMap was ramping up, I got my name on a paper for the first time, High - density single - nucleotide polymorphism maps of the human genome (Genomics, 86:2, 2005).
single nucleotide polymorphism Abbreviated SNP and pronounced snip, this is a common variation in a DNA base.
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.
Demonstration of loss of heterozygosity by single - nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection.
Furthermore, we use genetic testing to determine if any single nucleotide polymorphisms exist in the NFR2 pathway, which aids in personalizing one's supplement and treatment regimen.
SNP stands for Single - Nucleotide Polymorphism Read More
Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm.
Genome - wide patterns of nucleotide polymorphism in domesticated rice Caicedo, A. L., S. H. Williamson, R. D. Hernandez, A. Boyko et al. 2007.
Reconstituting the frequency spectrum of ascertained single - nucleotide polymorphism data Nielsen, R., M. J. Hubisz, and A. G. Clark.
Correcting estimators of θ and Tajima's D for ascertainment biases caused by the single - nucleotide polymorphism discovery process.
With DNA Compass, that you can upload your genome data to this website, then you can search for individual SNPs [single - nucleotide polymorphisms] in your genome or for specific traits — let's say hair color or skin pigmentation.
Linkage disequilibrium and inference of ancestral recombination in 538 single - nucleotide polymorphism clusters across the human genome Clark, A. G., R. Nielsen, J. Signorovitch, T. C. Matise et al. 2003.
To find out, Craig and his colleagues developed a mathematical strategy to search the pool for DNA variants called single - nucleotide polymorphisms from a known individual.
One of the tools, the SNP - Seek database, is designed to provide user - friendly access to a type of genetic marker called single nucleotide polymorphisms (SNPs) identified from this data.
In genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphisms).
Their preliminary analysis revealed several mutations known as single nucleotide polymorphisms (SNPs) in the ALR gene, many of which haven't been identified before.
Specifically, they focused on single - nucleotide polymorphisms (SNPs)-- variations that affect a single DNA building block.
Single - nucleotide polymorphisms (SNPs — pronounced «snips») are the most common type of human genetic variation; each one represents a small difference in a nucleotide — the building blocks of our DNA.
After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.
Instead they search specific regions of the genome for a type of mutation known as a single nucleotide polymorphism, or SNP (pronounced «snip»).
Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.
Fully sequenced genomes remain rare, so the bulk of the analysis was done by looking at genetic markers known as single nucleotide polymorphisms or SNPs.
They reveal 341 fixed substitutions (35 nonsynonymous, 173 synonymous, and 133 noncoding) between the 2014 EBOV and all previously published EBOV sequences, with an additional 55 single - nucleotide polymorphisms (SNPs; 15 nonsynonymous, 25 synonymous, and 15 noncoding), fixed within individual patients, within the West African outbreak.
Led by a team of world - renowned geneticists, our solutions are applicable for questions focused on single - nucleotide polymorphism discovery and diagnostics, marker - assisted selection, quantitative trait locus mapping, genome - wide association studies, phylogenomics, and more.
Wilmington, Delaware - based Incyte had a similar business model: The company owned a collection of single - nucleotide polymorphisms (SNPs)-- one - letter genetic «typos» — that had drug - discovery professionals drooling.
Collins calls these mutations «misspellings»; when a large number of people share the same mutation, they're known as single nucleotide polymorphisms (SNPs, pronounced «snips»).