Sentences with phrase «nucleotide polymorphisms associated»

Not exact matches

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

To identify new genetic variations associated with different SLE phenotypes, a total of 598,258 different regions on the genome (known as single - nucleotide polymorphisms) were genotyped in a population of 482 Caucasian European SLE patients of Spanish origin recruited from the rheumatology departments of 15 Spanish university hospitals belonging to the IMID Consortium (SLE group).

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

Their analysis identified new «extreme longevity - promoting variants» on chromosomes 4 and 7, while also confirming variants (SNPs, or single nucleotide polymorphisms) previously associated with longevity.

Hill showed a single - nucleotide polymorphism — placed in the genome where a single nucleotide is altered — in this gene is «strongly associated» with elite sprint racing performance.

The teams then scanned their respective databases for single - nucleotide polymorphisms — regions where the DNA differs by one base — that were associated with being either taller or shorter than average.

The study also tested whether 3 single - nucleotide polymorphism multilocus genotype responsiveness patterns or insulin secretion (INS - 30; blood concentration of insulin 30 minutes after a glucose challenge) were associated with weight loss.

We investigated whether haplogroup, single nucleotide polymorphisms (SNPs), or heteroplasmy of mitochondrial DNA (mtDNA) were associated with health status and / or symptoms.

The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

In the Diabetes Prevention Program, SHBG and SHBG - single nucleotide polymorphisms did not predict incident diabetes in any sex, but diabetes incidence was directly associated with estradiol and estron and inversely with testosterone in men (62).

To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).

Single nucleotide polymorphism -LRB--468 Gly to A) at the promoter region of SREBP - 1c associates with genetic defect of fructose - induced hepatic lipogenesis [corrected].

The human DAO gene spans ≈ 10 kbp and is located on chromosome 7q35 (27) Various single - nucleotide polymorphisms (SNPs) in the DAO gene have been shown to be associated with inflammatory and neoplastic gastrointestinal diseases, such as food allergy (44), gluten - sensitive enteropathy, Crohn disease, ulcerative colitis, and colon adenoma (45 — 47).

By replenishing the body with higher concentrations of vitamin or mineral enzyme co-factors, enzyme efficiency increases, and thus correction of SNP (single nucleotide polymorphism) genetic variants and associated enzyme abnormalities can be accomplished with safe nutritional supplements.

DetoxiGenomic ® Profile evaluates single nucleotide polymorphisms (SNPs) associated with increased risk of impaired detoxification capacity especially when exposed to environmental toxins.

We try to identify genetic markers (single nucleotide polymorphisms) that point to the associated or causal genes and the genes themselves underlying the development of canine hip dysplasia and secondary hip osteoarthritis.